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Opportunities and challenges of next-generation DNA sequencing for breast units.

Pilgrim(S M),Pain(S J),Tischkowitz(M D) Br J Surg 2014-07-30

...BRCA2, before the start of treatment. This could alter treatment decisions; for instance, more women might opt for maste...

Two decades after BRCA: setting paradigms in personalized cancer care and pre...

Couch(Fergus J),Nathanson(Katherine L),Off... Science 2014-04-10

The cloning of the breast cancer susceptibility genes BRCA1 and BRCA2 nearly two decades ago helped set in motion an ava...

Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.

Venkitaraman(Ashok R) Science 2014-04-10

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies, most notably tumors of the breast and ova...

Prospective study of high-risk, BRCA1/2-mutation negative women: the 'negativ...

Kotsopoulos(Joanne),Metcalfe(Kelly),Alston... BMC Cancer 2014-11-06

...BRCA2 (BRCA1/2) mutation were four times more likely to develop breast cancer compared to women in the general populatio...

Epstein Barr virus: a prime candidate of breast cancer aetiology in Sudanese ...

Yahia(Zeinab A),Adam(Ameera Am),Elgizouli(... Infect Agent Cancer 2014-03-17

...BRCA2 in Sudanese breast cancer patients, the methylation status of six tumor suppressor genes was investigated using me...

Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade...

Daniels(Molly S),Babb(Sheri A),King(Robin ... J Clin Oncol 2014-07-23

Identification of the 10% to 15% of patients with ovarian cancer who have germline BRCA1 or BRCA2 mutations is important...

Expression of EMSY, a novel BRCA2-link protein, is associated with lymph node...

Madjd(Zahra),Akbari(Mohammad Esmaeil),Zarn... Asian Pac J Cancer Prev 2014-11-18

...BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although ...

Molecular basis for impaired DNA damage response function associated with the...

Anamika,Markin(Craig J),Rout(Manoj K),Spyr... J Biol Chem 2014-08-02

...BRCA2 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chains. Mutations ...

Glucocorticoid receptor repression mediated by BRCA1 inactivation in ovarian ...

Fang(Yuan-Yuan),Li(Da),Cao(Chen),Li(Chun-Y... BMC Cancer 2014-11-06

...BRCA2-mutated and BRCA2-mutated ovarian cancer compared to their normal tissues; BRCA1 repression (BRCA1 mutation or BRC...

Promising outcomes of screening for pancreatic cancer by genetic testing and ...

Sud(Anchal),Wham(Deborah),Catalano(Marc),G... Pancreas 2014-12-16

...BRCA2 mutations. The patient with the intraductal papillary mucinous neoplasm had Peutz-Jeghers syndrome. All 3 patients...

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