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TP53 BRCA1 CRISPR single-cell cancer

Ashton-Prolla(Patricia),Vargas(Fernando Re... Genet Mol Biol 2014-04-25

...BRCA2 and TP53.

Willis(Nicholas A),Chandramouly(Gurushanka... Nature 2014-08-14

...BRCA2, control HR/SCR at stalled replication forks. Although BRCA1 and BRCA2 affect replication fork processing, direct ...

Cochran(Rory L),Cravero(Karen),Chu(David),... Hum Pathol 2014-08-21

...BRCA2 variant of unknown clinical significance (c.6966G>T; M2322I). Conventional PCR followed by Sanger sequencing sugge...

Friebel(Tara M),Domchek(Susan M),Rebbeck(T... J Natl Cancer Inst 2014-07-07

There is substantial variability in cancer risk in women who have inherited a BRCA1 or BRCA2 (BRCA1/2) mutation. Numerou...

Saadatmand(Sepideh),Vos(Janet R),Hooning(M... Int J Cancer 2014-12-09

...BRCA2 mutation carriers, and first breast cancers separately. Over 70% of 60-year old BRCA1/2 mutation carriers remain a...

Mainetti(Leandro E),Zhe(Xiaoning),Diedrich... Int J Cancer 2014-12-22

...BRCA2 downregulation. Gene rescue experiments with human BRCA2 transgene in c-kit-transfected PCa cells resulted in redu...

Tavtigian(Sean V),Chenevix-Trench(Georgia) Biomark Med 2014-12-17

...BRCA2, PALB2 and BRIP1 stand as examples where the majority of mutations lead to protein truncation;TP53 provides a coun...

Finch(Amy P M),Lubinski(Jan),Møller(Pål),S... J Clin Oncol 2014-07-03

...BRCA2 mutation after oophorectomy, by age of oophorectomy; to estimate the impact of prophylactic oophorectomy on all-ca...

Topp(Monique D),Hartley(Lynne),Cook(Michel... Mol Oncol 2014-12-17

...BRCA2, and in two, BRCA1 was methylated. In vivo cisplatin response, determined as platinum sensitive (progression-free ...

Patel(Maulik R),Bhatt(Aaditya),Steffen(Jam... J Med Chem 2014-09-05

...BRCA2-deficient DT40 cells. Crystal structures of three inhibitors (compounds (-)-13c, 59, and 65) bound to a multidomai...

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