Germ line mutations in BRCA1 and BRCA2 (BRCA1/2) and other susceptibility genes have been identified as genetic causes o...
...BRCA2, or other gene predisposing to a markedly increased risk of breast cancer, untested first-degree relative of a gen...
...BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, ...
...Brca2 inactivation in neural progenitors also led to ablation of cerebellar interneurons, but this did not require Atm. ...
...BRCA2-mutant cancers, checkpoint inhibitors for p53 mutant cancers, and small molecule agents targeting RAS gene mutant ...
...BRCA2-depleted cells. The results indicate that R-loops are frequently formed in cells and that BRCA2 is required for th...
...BRCA2, have now been identified. A suspicion of a diagnosis of prostate cancer is usually based on either induration or ...
...BRCA2 (breast cancer early-onset 2)] [corrected] has emerged as a key player in the maintenance of genome integrity. Bia...
...BRCA2 mutation carriers (gBRCAm). We hypothesized addition of olaparib to carboplatin can be administered safely and yie...
...BRCA2, BAP1 and the promoter of TERT have also been linked to the disease. Here we set out to identify new high-penetran...
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