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TP53 BRCA1 CRISPR single-cell cancer

Finch(Amy P M),Lubinski(Jan),Møller(Pål),S... J Clin Oncol 2014-07-03

...BRCA2 mutation after oophorectomy, by age of oophorectomy; to estimate the impact of prophylactic oophorectomy on all-ca...

Mundia(Maureen M),Desai(Vatsal),Magwood(Al... Genetics 2014-12-22

...BRCA2, but not a BRCA2 variant devoid of BRC repeats 1-8, rescues the 3' extension defect in these cells. Our results su...

Hoskins(Lindsey M),Werner-Lin(Allison),Gre... PLoS One 2014-11-04

...BRCA2 face a unique set of challenges related to managing cancer risk during a demographically-dense stage of life. They...

Floquet(Anne),Stoeckle(Eberhard),Croce(Sab... Bull Cancer 2014-05-01

...BRCA2 genes mutations, and the Lynch syndrome with mutated MMR genes is the other. Alterations in homologous recombinati...

Joshi(Poorval M),Sutor(Shari L),Huntoon(Ca... J Biol Chem 2014-05-21

Mutations in the tumor suppressors BRCA1 and BRCA2, which encode proteins that are key participants in homologous recomb...

De Summa(S),Pinto(R),Pilato(B),Sambiasi(D)... Cell Death Dis 2014-10-21

...BRCA2-related patients concurrently with no change in PARP1 expression. Interestingly, no difference in PARP1 and miR17 ...

Topp(Monique D),Hartley(Lynne),Cook(Michel... Mol Oncol 2014-12-17

...BRCA2, and in two, BRCA1 was methylated. In vivo cisplatin response, determined as platinum sensitive (progression-free ...

Davis(Luther),Maizels(Nancy) Proc Natl Acad Sci U S A 2014-05-08

...BRCA2; or by an efficient alternative pathway that uses either ssDNA or nicked dsDNA donors and that is strongly inhibit...

Larsen(Martin J),Thomassen(Mads),Tan(Qihua... BMC Med Genomics 2014-09-03

In more than 70% of families with a strong history of breast and ovarian cancers, pathogenic mutation in BRCA1 or BRCA2 ...

George(Sophia H L),Shaw(Patricia) Front Oncol 2014-06-24

...BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer (EOC), and epidemiologica...

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