...BRCA2, and 11 other genes in the homologous recombination pathway.,Thirty-one percent of ovarian carcinomas had a delete...
...BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with ge...
...BRCA2 tumor suppressor proteins, which are involved in the repair of DNA damage. Although this approach has shown promis...
...BRCA2 tumor-suppressor genes account for the majority of hereditary breast cancer cases. The BRCA1 C-terminal region (BR...
...BRCA2 and p53) from nine mammals. The opossum (a marsupial) was used as an out-group species for both sets of sequences....
...BRCA2-associated cancers. However, not all patients respond equally well and tumors may eventually become resistant. Thu...
...BRCA2, RAD51, poly(ADP ribose) polymerase (PARP), and gamma-H2AX to dysregulate DNA damage response. Aurora-A may also i...
...BRCA2 gene. Individuals heterozygous for BRCA2 mutations have an increased risk of inherited breast and ovarian cancer. ...
...Brca2) protein. Additionally, hybridoma cell lines that are siRNA depleted for mouse Brca2 show a corresponding reductio...
...BRCA2 mutations. One case underwent risk-reductive salpingo-oophorectomy as a BRCA1 mutant carrier was retrospectively d...
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