...BRCA2-deficient DT40 cells. Crystal structures of three inhibitors (compounds (-)-13c, 59, and 65) bound to a multidomai...
...BRCA2, have an increased risk of solid tumors. Tumors in the kidneys of these patients are almost exclusively Wilms tumo...
The screening of BRCA1 and BRCA2 mutations is now an established component of risk evaluation and management of familial...
...BRCA2 germline mutation presenting with primary squamous cell carcinoma of the pancreas as the only malignancy. The tumo...
...BRCA2-negative, PIK3CA mutation (p.His1047Arg) positive presented with diffuse bony metastases and bone pain. She had ho...
...BRCA2 mutations, medical disorders causing hyperestrogenism, or radiation exposure.
...BRCA2. The majority of breast cancers arising in carriers of BRCA1 germ-line mutations, as well as half of those in BRCA...
...BRCA2 mutations are hypersensitive to inhibition of poly(ADP-ribose) polymerase-1 (PARP-1). We recently showed that inte...
Missense variants in the BRCA2 gene are routinely detected during clinical screening for pathogenic mutations in patient...
...BRCA2-mutated or not, and 22 pairs with hypermethylated BRCA1 promoter or not). BRCA1 promoter methylation was analyzed ...
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