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TP53 BRCA1 CRISPR single-cell cancer

Zhang(Jian),Shi(Yuhao),Lalonde(Emilie),Li(... BMC Cancer 2013-09-16

Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in...

Sitzmann(James V),Wiebke(Eric A) JAMA Surg 2013-05-23

Risk-reducing bilateral salpingo-oophorectomy (RRBSO) and risk-reducing mastectomy are widely used for BRCA1 and BRCA2 m...

Liška(František),Gosele(Claudia),Popova(El... PLoS One 2013-10-22

...BRCA2-interacting protein) truncation at the C-terminus in the hd mutant. Here, we report data from a transgenic rescue ...

Subramanyam(Shyamal),Jones(William T),Spie... Nucleic Acids Res 2013-12-30

...BRCA2 protein, a product of the breast cancer susceptibility gene, is a key recombination mediator that interacts with R...

Southey(Melissa C),Teo(Zhi L),Winship(Ingrid) Appl Clin Genet 2013-08-12

...BRCA2, the research community moved to candidate gene studies that led to the identification of ATM, BRIP1, CHEK2, and P...

Legartová(Soňa),Stixová(Lenka),Strnad(Hyne... Epigenomics 2013-11-14

...BRCA2, were significantly downregulated by SAHA. However, MG149 had no effect on the investigated nuclear processes, wit...

Phillips(Kelly-Anne),Milne(Roger L),Rookus... J Clin Oncol 2013-10-29

...BRCA2 mutation carriers.,Analysis of pooled observational cohort data, self-reported at enrollment and at follow-up from...

Tian(Chunqiao Q),Darcy(Kathleen M),Krivak(... Front Oncol 2013-08-21

...BRCA2 in epithelial ovarian cancer (EOC). This study evaluated whether common variants of BRCA1/BRCA2 are associated wit...

Solano(Angela Rosaria),Aceto(Gitana Maria)... Springerplus 2013-08-20

...BRCA2).,We found 24 deleterious mutations (BRCA1:16; BRCA2: 8) in 38/134 (28.3%) patients, of which 6/37 (16.2%) within ...

Calderón-Montaño(José Manuel),Burgos-Morón... Toxicol Lett 2013-10-29

...BRCA2 (deficient in homologous recombination repair) were significantly hypersensitive to the cytotoxic activity of 2-py...

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