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Zhang(J),Sun(X),Zhou(Q),Wei(Y),Chen(B),Jia... J Med Chem 2026-02-12

...BRCA2-/-). Moreover, compound 20 demonstrated favorable pharmacokinetic properties, with oral bioavailability values of ...

Buecher(B),Warcoin(M),Rolland(E),Abdullazo... Eur J Hum Genet 2026-01-29

...BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51C, RAD51D, STK11) was performed in 496 patients with pancreatic ducta...

Michaelson-Cohen(R),Armon(S),Srebnik(N),Vo... Isr J Health Policy Res 2026-01-30

...BRCA2 pathogenic variants (PVs) in 2020 has led to a significant increase in the number of unaffected female carriers wh...

Saida(T),Shikama(A),Yoshida(M),Amano(T),Is... Magn Reson Med Sci 2026-01-27

...BRCA2 variant, and 22 without BRCA variants) and 18 patients with HRD-negative HGSC were included. The HRD-negative pati...

Monteagudo-García(Ó),Nombela(P),Román(ÁC),... Cancer Res 2026-02-02

...BRCA2 occurred in patients with metastatic prostate cancer. Functional in vitro and in vivo assays demonstrated that ZC3...

Zuo(Y),Zhang(K),Zhang(M),Wang(T),Zhu(Y),Wa... Eur J Med Chem 2026-01-15

...BRCA2. Exploring the relationship between Polθ and cancer may offer new therapeutic strategies. This review outlines the...

Browne(IM),Pascual(J),Cutts(RJ),Kingston(B... Clin Cancer Res 2026-01-06

...BRCA2/PALB2 wild type. Baseline low ctDNA levels predict response to targeted therapy, potentially suggesting shared mec...

Evans(DG),Morgan(RD),Forde(C),Crosbie(EJ),... J Med Genet 2026-01-20

Genetic testing for (likely) pathogenic variants (PVs) in BRCA1/BRCA2 has been performed in Manchester since 1996, with ...

Jiang(Y),Yi(Q),Wang(Y),Li(C),Liu(H) Anticancer Drugs 2026-06-01

...BRCA2 mutation and HRD-positive status. Imaging assessments revealed significant tumor reduction without disease progres...

Matos(AC),Lima(M),Miranda-Gonçalves(V),Ind... Cancer Lett 2026-02-28

...BRCA2, ATM, and PARP1, on RT response, highlighting their potential as therapeutic targets to overcome RR. We further ex...