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Hereditary gynaecological malignancies: advances in screening and treatment.

Folkins(Ann K),Longacre(Teri A) Histopathology 2013-06-13

...BRCA2 genes in ovarian cancer and the mismatch repair genes in endometrial carcinoma has revolutionized our approach to ...

Heterozygous mutations in the PALB2 hereditary breast cancer predisposition g...

Wark(Landon),Novak(David),Sabbaghian(Nelly... Genes Chromosomes Cancer 2013-08-26

...BRCA2-interacting Fanconi Anemia (FA) protein crucial for key BRCA2 genome caretaker functions. Heterozygous germline mu...

Determination of molecular markers for BRCA1 and BRCA2 heterozygosity using g...

Salmon(Asher Y),Salmon-Divon(Mali),Zahavi(... Cancer Prev Res (Phila) 2013-07-19

...BRCA2. We searched for genes that have the potential to distinguish healthy BRCA1 and BRCA2 mutation carriers from nonca...

Prophylactic mastectomy: an appraisal.

Zagouri(Flora),Chrysikos(Dimosthenis T),Se... Am Surg 2013-03-18

...BRCA2 mutation carriers. Prophylactic mastectomy includes the simple method and the subcutaneous method. Both methods ca...

Using a fragment-based approach to target protein-protein interactions.

Scott(Duncan E),Ehebauer(Matthias T),Pukal... Chembiochem 2013-08-15

...BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect ...

A new rapid methodological strategy to assess BRCA mutational status.

Vuttariello(Emilia),Borra(Marco),Calise(Ce... Mol Biotechnol 2013-11-04

Hereditary cancers account for approximately 10 % of breast and ovarian cancers. Mutations of the BRCA1 and BRCA2 genes,...

[Descriptive epidemiology and molecular genetics of hereditary breast cancer ...

García-Jiménez(Laura),Gutiérrez-Espeleta(G... Rev Biol Trop 2013-04-30

...BRCA2 mutations. These mutations were detected by different techniques and were confirmed by direct sequencing. Six pati...

Outcome of metastatic breast cancer in selected women with or without deleter...

Bayraktar(S),Gutierrez-Barrera(A M),Lin(H)... Clin Exp Metastasis 2013-07-19

...BRCA2 carriers and 37 % in non-carriers (P = 0.001). Median follow-up was 2.8 years. BRCA non-carriers and BRCA2 carrier...

Mutation analysis of the SHFM1 gene in breast/ovarian cancer families.

Bonache(Sandra),de la Hoya(Miguel),Gutierr... J Cancer Res Clin Oncol 2013-04-18

...BRCA2 protein and is required for BRCA2 stability and function, making a critical contribution to the BRCA2 function in ...

Variants of uncertain significance in BRCA1 and BRCA2 assessment of in silico...

Moghadasi(Setareh),Hofland(Nandy),Wouts(Jo... J Med Genet 2013-10-28

Nearly 15% of BRCA1 and BRCA2 DNA tests lead to the identification of Variants of Uncertain Significance (VUS). VUS are ...

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