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RAS promotes tumorigenesis through genomic instability induced by imbalanced ...

Yang(Gong),Mercado-Uribe(Imelda),Multani(A... Int J Cancer 2013-07-11

...BRCA2 in ovarian cancer cell lines and tumor samples containing RAS mutations. We found that Aurora-A and BRCA2 inversel...

Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA ...

Calderón-Montaño(José Manuel),Burgos-Morón... Toxicol Lett 2013-10-29

...BRCA2 (deficient in homologous recombination repair) were significantly hypersensitive to the cytotoxic activity of 2-py...

Breast cancer in women aged 25 years and younger.

Dimitrakakis(Constantine),Tsigginou(Alexan... Obstet Gynecol 2013-09-17

...BRCA2 mutations was performed in 12 of 28 young patients and mutations were found in 25% of them. Moreover, young women ...

[Molecular basis of gynecological oncology - TopBP1 protein as the guardian o...

Forma(Ewa),Wójcik-Krowiranda(Katarzyna),Bi... Ginekol Pol 2013-07-25

...BRCA2, have been identified. Recent findings suggest TopBP1 to be a breast and ovarian cancer susceptibility gene. Moreo...

[Prophylactic surgery in common hereditary cancer syndromes].

Noguès(Catherine),Mouret-Fourme(Emmanuelle... Bull Acad Natl Med 2013-07-17

...BRCA2 mutation carriers. Bilateral prophylactic salpingo-oophorectomy is recommended for BRCA1/ BRCA2 carriers: women wh...

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetic...

Killick(Emma),Morgan(Richard),Launchbury(F... Sci Rep 2013-10-17

...BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. ...

Personalized synthetic lethality induced by targeting RAD52 in leukemias iden...

Cramer-Morales(Kimberly),Nieborowska-Skors... Blood 2013-11-07

...BRCA2 genes, and gene expression profiles identifying leukemias displaying low levels of BRCA1 and/or BRCA2. We believe ...

The genetics of breast cancer: risk factors for disease.

Collins(Andrew),Politopoulos(Ioannis) Appl Clin Genet 2013-06-19

...BRCA2, a number of rare cancer syndrome genes, and rare genes with more moderate penetrance. A larger group of common va...

Localization of BRCA1 protein in breast cancer tissue and cell lines with mut...

Tulchin(Natalie),Ornstein(Leonard),Dikman(... Cancer Cell Int 2013-07-24

...BRCA2 (6174delT). We also compared co-localization of BRCA1 and nucleolin in MCF7 cells (wild type) and a mutant BRCA1 c...

Loss of heterozygosity preferentially occurs in early replicating regions in ...

Pedersen(Brent S),De(Subhajyoti) Nucleic Acids Res 2013-11-05

...BRCA2 mutation status. The LOH events are significantly clustered near RNA polII-bound transcription start sites, consis...

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