...BRCA2 form a filament on the 3' DNA strand at a break to enable annealing to the complementary sister chromatid while th...
...BRCA2-DSS1 binding render BRCA2 cytoplasmic. In turn, cytoplasmic mislocalization of mutant BRCA2 inhibits the nuclear r...
...BRCA2 genes. The BRCA1 and BRCA2 gene mutations strikingly increase breast cancer risk, suggesting that polymorphisms in...
...BRCA2 mutation carriers more accurately perceived their risk for contralateral breast cancer, whereas women without a kn...
...BRCA2 mutation carriers and 462 noncarrier relatives.,We found no evidence that BRCA1 and BRCA2 mutation carriers are at...
...BRCA2 and NBS1 genes cause inherited recessive chromosomal instability syndromes and predispose to prostate cancer of po...
...BRCA2, and had no other known breast cancer risks. Their breast imaging is reviewed, showing clustering of multiple tumo...
...BRCA2 have been well investigated. These genes are widely accepted as the predisposing factors that trigger malignant tr...
Penetrance for breast cancer, ovarian cancer, or both in carriers of BRCA1/BRCA2 mutations is disproportionately high. S...
...BRCA2. Additionally, two patients (1.0%) had mutations in both genes. Cancers in patients with BRCA1 mutations more freq...
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