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TP53 BRCA1 CRISPR single-cell cancer

Ouyang(Karen J),Yagle(Mary K),Matunis(Mich... Front Genet 2013-09-12

...BRCA2 and RAD52, which normally substitute RAD51 for RPA on ssDNA, failed to accumulate normally at stalled forks; inste...

Lorusso(D),Cirillo(F),Mancini(M),Spatti(G ... Oncology 2013-10-28

...BRCA2 patients, respectively (p = 0.03). Median OS was 77.23 and 111.47 months for BRCA1 and BRCA2 patients, respectivel...

Haanpää(Maria),Pylkäs(Katri),Moilanen(Jukk... BMC Med Genet 2013-09-09

Testing for mutations in the BRCA1 and BRCA2 genes among high-risk breast cancer patients has become a routine practice ...

Legartová(Soňa),Stixová(Lenka),Strnad(Hyne... Epigenomics 2013-11-14

...BRCA2, were significantly downregulated by SAHA. However, MG149 had no effect on the investigated nuclear processes, wit...

Phillips(Kelly-Anne),Milne(Roger L),Rookus... J Clin Oncol 2013-10-29

...BRCA2 mutation carriers.,Analysis of pooled observational cohort data, self-reported at enrollment and at follow-up from...

Tian(Chunqiao Q),Darcy(Kathleen M),Krivak(... Front Oncol 2013-08-21

...BRCA2 in epithelial ovarian cancer (EOC). This study evaluated whether common variants of BRCA1/BRCA2 are associated wit...

Solano(Angela Rosaria),Aceto(Gitana Maria)... Springerplus 2013-08-20

...BRCA2).,We found 24 deleterious mutations (BRCA1:16; BRCA2: 8) in 38/134 (28.3%) patients, of which 6/37 (16.2%) within ...

Subramanyam(Shyamal),Jones(William T),Spie... Nucleic Acids Res 2013-12-30

...BRCA2 protein, a product of the breast cancer susceptibility gene, is a key recombination mediator that interacts with R...

Southey(Melissa C),Teo(Zhi L),Winship(Ingrid) Appl Clin Genet 2013-08-12

...BRCA2, the research community moved to candidate gene studies that led to the identification of ATM, BRIP1, CHEK2, and P...

Metcalfe(K A),Poll(A),Royer(R),Nanda(S),Ll... Br J Cancer 2013-11-25

...BRCA2 stipulate that a personal or family history of cancer is necessary to be eligible for testing. Approximately 2% of...

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