The relevance of many BRCA2 variants of uncertain significance (VUS) to breast cancer has not been determined due to lim...
...BRCA2 germline mutation attending a tertiary multidisciplinary clinic. A consecutive series of women with a BRCA1 or BRC...
...BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4,...
...BRCA2 pathway of homologous recombination. Biochemical studies also showed significant differences between yeast and hum...
...BRCA2, have been found in most cases of inherited human breast cancer. Similarly, the canine BRCA2 gene locus has been a...
The objective is to estimate the risk of breast cancer in women who carry a deleterious BRCA1 or BRCA2 mutation, accordi...
Germline mutations in the BRCA1 or BRCA2 genes are associated with an increased risk of breast and ovarian cancer develo...
...BRCA2; n = 60) were tested for the MDM2 polymorphisms. Results were compared to healthy controls (n = 2,465).,The SNP309...
...BRCA2, or RAD51. Furthermore, RNF168-depleted cells can form ionizing radiation-induced foci of the recombinase RAD51 wi...
Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance ...
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