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Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with bre...

Stadler(Zsofia K),Salo-Mullen(Erin),Patil(... Cancer 2012-02-28

Germline mutations in the BRCA2 cancer susceptibility gene are associated with an increased risk of pancreatic cancer (P...

Psychological impact of recall on women with BRCA mutations undergoing MRI su...

Spiegel(Tirtza N),Esplen(Mary Jane),Hill(K... Breast 2012-01-27

...BRCA2) completed study instruments at T1 and T2, and 48 at T3. Eighteen women (32%) were recalled for additional imaging...

Clinical implications for BRCA gene mutation in breast cancer.

Xu(Jin),Wang(Baosheng),Zhang(Yanjun),Li(Ru... Mol Biol Rep 2012-05-25

To investigate the mutations of BRCA1 and BRCA2 and determine whether clinic-pathological factors related to BRCA gene m...

Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-...

Rego(M A),Harney(J A),Mauro(M),Shen(M),How... Oncogene 2012-03-26

...BRCA2 function cooperatively in the FA-BRCA pathway to repair damaged DNA. Activation of the FA-BRCA pathway occurs via ...

Contribution of bioinformatics predictions and functional splicing assays to ...

Théry(Jean Christophe),Krieger(Sophie),Gai... Eur J Hum Genet 2012-01-11

...BRCA2 may induce splicing defects. We analyzed 53 VUSs of BRCA1 or BRCA2, detected in consecutive molecular screenings, ...

MUTYH gene variants and breast cancer in a Dutch case–control study.

Out(Astrid A),Wasielewski(Marijke),Huijts(... Breast Cancer Res Treat 2012-11-19

...BRCA2 mutation (BRCAx cohort), and 1,666 controls. First, for 303 consecutive patients diagnosed before age 55 years and...

Practicalities of developing a breast magnetic resonance imaging screening se...

Kiely(Belinda E),Hossack(Lucinda K),Shadbo... ANZ J Surg 2012-05-15

...BRCA2 gene mutation were invited to undergo annual breast screening with MRI in addition to mammography and clinical bre...

Long-term psychosocial outcomes of BRCA1/BRCA2 testing: differences across af...

Graves(Kristi D),Vegella(Patti),Poggi(Eliz... Cancer Epidemiol Biomarkers... 2012-07-12

...BRCA2 (BRCA1/2) testing; however, little research has examined the long-term impact of testing. We conducted the first l...

The protein kinase Akt1 regulates the interferon response through phosphoryla...

Ezell(Scott A),Polytarchou(Christos),Hatzi... Proc Natl Acad Sci U S A 2012-05-04

...BRCA2 that functions as a transcriptional repressor. Overexpression of EMSY in hTERT-immortalized mammary epithelial cel...

Prevalence of TP53 germ line mutations in young Pakistani breast cancer patie...

Rashid(Muhammad U),Gull(Sidra),Asghar(Kash... Fam Cancer 2012-11-30

...BRCA2, the genetic causes of the majority of early-onset cases are unexplained. Since germ line mutations in the tumor s...

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