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The protein kinase Akt1 regulates the interferon response through phosphoryla...

Ezell(Scott A),Polytarchou(Christos),Hatzi... Proc Natl Acad Sci U S A 2012-05-04

...BRCA2 that functions as a transcriptional repressor. Overexpression of EMSY in hTERT-immortalized mammary epithelial cel...

Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review.

Bougie(O),Weberpals(J I) Int J Surg Oncol 2012-08-23

...BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a resu...

MUTYH gene variants and breast cancer in a Dutch case–control study.

Out(Astrid A),Wasielewski(Marijke),Huijts(... Breast Cancer Res Treat 2012-11-19

...BRCA2 mutation (BRCAx cohort), and 1,666 controls. First, for 303 consecutive patients diagnosed before age 55 years and...

Practicalities of developing a breast magnetic resonance imaging screening se...

Kiely(Belinda E),Hossack(Lucinda K),Shadbo... ANZ J Surg 2012-05-15

...BRCA2 gene mutation were invited to undergo annual breast screening with MRI in addition to mammography and clinical bre...

Prevalence of TP53 germ line mutations in young Pakistani breast cancer patie...

Rashid(Muhammad U),Gull(Sidra),Asghar(Kash... Fam Cancer 2012-11-30

...BRCA2, the genetic causes of the majority of early-onset cases are unexplained. Since germ line mutations in the tumor s...

BRCA1 and BRCA2 mutations correlate with TP53 abnormalities and presence of i...

McAlpine(Jessica N),Porter(Henry),Köbel(Ma... Mod Pathol 2012-08-23

...BRCA2 mutations. Histopathology, germline and somatic BRCA1 or BRCA2 mutations, BRCA1 methylation, and BRCA1 and BRCA2 m...

Epigenetic modification and cancer: mark or stamp?

Foulkes(William D) Endocr Relat Cancer 2012-10-17

...BRCA2 germline mutation carriers' by Bijron et al. published in the February 2012 issue of Endocrine-Related Cancer, the...

APRIN is a cell cycle specific BRCA2-interacting protein required for genome ...

Brough(Rachel),Bajrami(Ilirjana),Vatcheva(... EMBO J 2012-05-03

...BRCA2 confer an increased risk of cancer development, at least in part because the BRCA2 protein is required for the mai...

The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutat...

Laitman(Yael),Kuchenbaecker(Karoline B),Ra... Breast Cancer Res Treat 2012-08-22

...BRCA2 mutation carriers has not been reported. The KL-VS variant was genotyped in women of European ancestry carrying a ...

Prevalence of BRCA mutations in an unselected population of triple-negative b...

Hartman(Anne-Renee),Kaldate(Rajesh R),Sail... Cancer 2012-07-27

This study assessed BRCA1 and BRCA2 mutation prevalence in an unselected cohort of patients with triple-negative breast ...

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