...BRCA2 and other high-penetrance gene mutations, can identify women at elevated risk, enabling proactive surveillance, ri...
...BRCA2 and ATM were the most frequently mutated genes (1.67% each), showing significant enrichment compared with all cont...
...BRCA2, and TP53, while P5 in MDA-MB-231 spheroids produced the strongest repression of survival and DNA-repair pathways....
...BRCA2, and 9 patients (18%) with other DNA repair-related genes-7 (14%) RAD51C/D, 1 (2%) PALB2, and 1 (2%) CHEK2. The me...
...BRCA2. PARP inhibitors generate replication stress, creating a dependence on HR to repair the resulting DNA damage. Howe...
...BRCA2 constructs harboring each variant were introduced into BRCA2-knockout DLD-1 cells. Functional consequences were ev...
...BRCA2, and TP53. Germline BRCA1 alterations were reported at a relatively high frequency in several cohorts, most notabl...
...BRCA2 mutations, could reveal insights into both familial and non-familial causes of breast cancer. Australian Governmen...
...BRCA2, MLH1, and MSH2 showed that our framework achieved the best performance in the gene-specific setup for BRCA1—likel...
...BRCA2 [c.6509A>G; p.Lys2170Arg; c.7879A>T; p.Ile2627Phe; c.5574_5577delAATT; p.Ile1859LysfsTer3], PALB2 [c.1592delT; p.L...
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