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Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA…

Solyom(Szilvia),Aressy(Bernadette),Pylkäs(Ka… Sci Transl Med 2012-09-27

...BRCA2, and their interacting partners confer hereditary susceptibility to breast cancer. Abraxas directly interacts with...

Breast and ovarian cancer risk evaluation in families with a disease-causing mu…

Beristain(Elena),Ibáñez(Berta),Vergara(Itzia… J Community Genet 2012-10-02

...BRCA2, whereas the probability of developing ovarian cancer is about 37% and 25% for BRCA1 and BRCA2, respectively. Ther...

A diagnostic genetic test for the physical mapping of germline rearrangements i…

Cheeseman(Kevin),Rouleau(Etienne),Vannier(An… Hum Mutat 2012-09-06

The BRCA1 and BRCA2 genes are involved in breast and ovarian cancer susceptibility. About 2 to 4% of breast cancer patie...

Interactions between BRCA2 and RAD51 for promoting homologous recombination in …

Genois(Marie-Michelle),Mukherjee(Angana),Ube… Nucleic Acids Res 2012-11-05

...BRCA2. The biochemical interplay between RAD51 and BRCA2 is unknown in Leishmania or Trypanosoma. Here we show that the ...

Guidelines for splicing analysis in molecular diagnosis derived from a set of 3…

Houdayer(Claude),Caux-Moncoutier(Virginie),K… Hum Mutat 2012-11-28

...BRCA2 splice study to date by testing 272 VUSs (327 analyses) within the BRCA splice network of Unicancer. All these VUS...

Mre11-dependent degradation of stalled DNA replication forks is prevented by BR…

Ying(Songmin),Hamdy(Freddie C),Helleday(Thom… Cancer Res 2012-08-10

...BRCA2-deficient cells. BRCA2-deficient cells also showed hypersensitivity to the Mre11 inhibitor mirin. Interestingly, P...

Shorter telomere length is associated with increased ovarian cancer risk in bot…

Martinez-Delgado(Beatriz),Yanowsky(Kira),Ing… J Med Genet 2012-11-19

...BRCA2 are modifiers of telomere length (TL) in familial breast cancer. The present study analysed TL in peripheral blood...

[Present status and tasks for genetic testing and risk-reducing surgery in pati…

Arai(Masami),Taki(Keiko),Iwase(Haruko),Takiz… Gan To Kagaku Ryoho 2012-06-18

...BRCA2, the genes responsible for HBOC, is performed to diagnose HBOC. PCR-direct sequencing is a standard method used fo...

[Cellular functions of BRCA genes - from basic science to therapeutics].

Miki(Yoshio) Gan To Kagaku Ryoho 2012-06-18

...BRCA2 interacts with Rad51 to directly repair DNA damage. In addition, BRCA2 regulates cytokinesis and centrosome duplic...

[The clinical study of familial breast cancer - now and the problems].

Nomizu(Tadashi),Matsuzaki(Masami),Katagata(N… Gan To Kagaku Ryoho 2012-06-18

...BRCA2. This disease is called hereditary breast ovarian cancer syndrome (HBOC)because breast cancer and ovarian cancer a...

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