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TP53 BRCA1 CRISPR single-cell cancer

Sekine(Masayuki),Yoshihara(Kosuke),Tanaka(Ke… Gan To Kagaku Ryoho 2012-06-18

...BRCA2 mutations are less common than BRCA1 mutations in ovarian cancer families. A high proportion of serous adenocarcin...

Ledermann(Jonathan),Harter(Philipp),Gourley(… N Engl J Med 2012-04-19

...BRCA2 germline mutations.,We conducted a randomized, double-blind, placebo-controlled, phase 2 study to evaluate mainten...

Nishihori(Taiga),Alekshun(Todd J),Shain(Kenn… Br J Haematol 2012-07-09

...BRCA2 (P = 0·0072) and FANCF (P = 0·0458) mRNA following bortezomib treatment. Bortezomib combined with high-dose melpha...

Vreeswijk(Maaike P G),van der Klift(Heleen M) Methods Mol Biol 2012-07-23

...BRCA2 in breast cancer and MSH2, MSH6, MLH1, and PSM2 in hereditary nonpolyposis colorectal cancer (HNPCC, more recently...

Basu(Bristi),Yap(Timothy A),Molife(L Rhoda),… Curr Opin Oncol 2012-06-19

The success of poly(ADP-ribose) polymerase inhibition in BRCA1 or BRCA2 deficient tumors as an anticancer strategy provi...

Rouleau(E),Jesson(B),Briaux(A),Nogues(C),Cha… Breast Cancer Res Treat 2012-11-06

...BRCA2 genes. However, many families with breast cancer predisposition do not carry any known mutations for BRCA1 and BRC...

Fernández-Rodríguez(Juana),Quiles(Francisco)… BMC Cancer 2012-06-25

...BRCA2 has been completed, with globally negative results.,The genomic region of SLX4, comprising all exons and exon-intr...

Laitman(Yael),Simeonov(Monica),Herskovitz(Li… Breast Cancer Res Treat 2012-11-06

...BRCA2 (8765delAG). A few additional recurring mutations [A1708E, 981delAT, C61G (BRCA1) R2336P, and IVS2 + 1G > A (BRCA2...

Warrener(Paul),Kim(Sammy),Williams(Sybil M G… Apoptosis 2012-12-21

...BRCA2 function in a complex gene network that regulates homologous recombination and DNA double-strand break repair. Dis...

Ho(Alice Y),Gupta(Gaorav),King(Tari A),Perez… Cancer 2012-12-13

...BRCA2 mutations, and 23 women had no mutations. For the entire group, the 5-year local recurrence-free survival rate was...

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