...BRCA2 might play a role in the etiology. This study was conducted to screen for mutations of BRCA2 gene in ESCC cases fr...
...BRCA2 deficiencies. We selected 43 high-grade serous carcinomas diagnosed at Memorial Sloan-Kettering Cancer Center that...
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of g...
...BRCA2-deficient cells, has shown promising clinical efficacy in nonrandomized phase II trials in patients with ovarian c...
...BRCA2 cause gross chromosomal rearrangements. Chromosome structural instability in the absence of BRCA2 is thought to re...
...BRCA2, and the ATR-Chk1 signaling pathway, involving Rad9 and Rad17, significantly contribute to 5-FU tolerance. 5-FU in...
...BRCA2 mutation restoring HR function in the resistant lineage re-stabilized its genome and reduced platinum sensitivity....
...BRCA2 be referred for genetic counseling and evaluation for BRCA testing.,Through a cooperative agreement with the Cente...
...BRCA2 germline mutations, especially if at a young age. Screening paradigms based on molecular and morphological feature...
...BRCA2 in HR, we created fusions consisting of various BRCA2 domains and also introduced mutations into these domains to ...
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