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Relative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast…

Comen(E),Davids(M),Kirchhoff(T),Hudis(C),Off… Breast Cancer Res Treat 2012-09-14

Approximately 10% of Ashkenazi Jewish (AJ) women with breast cancer (BC) carry a founder mutation in BRCA1 or BRCA2. The...

Law-medicine interfacing: patenting of human genes and mutations.

Fialho(Arsenio M),Chakrabarty(Ananda M) Recent Pat DNA Gene Seq 2012-02-03

...BRCA2 gene patents, in the eligibility of all human and presumably other gene patents. This article argues that while pa...

Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families neg…

Manoukian(Siranoush),Peissel(Bernard),Friger… Breast Cancer Res Treat 2012-09-14

...BRCA2, and TP53 genes. Two cases harbored previously unreported mutations in CHEK2, the c.507delT and c.38A>G, leading t...

Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breas…

Stadler(Zsofia K),Salo-Mullen(Erin),Patil(Su… Cancer 2012-02-28

Germline mutations in the BRCA2 cancer susceptibility gene are associated with an increased risk of pancreatic cancer (P...

Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenoc…

Sonnenblick(Amir),Kadouri(Luna),Appelbaum(Li… Cancer Biol Ther 2012-02-06

Carriers of a germline mutation in the BRCA genes, in particular BRCA2, have an increased risk of developing pancreatic ...

Prevalence and characterization of BRCA1 and BRCA2 germline mutations in Chines…

Zhang(Juan),Pei(Renguang),Pang(Zhiyuan),Ouya… Breast Cancer Res Treat 2012-06-22

...BRCA2 mutations were 3.9% (16/409) and 6.6% (27/409), respectively; the mutation rate of BRCA2 was 1.7-fold higher than ...

Two patients with germline mutations in both BRCA1 and BRCA2 discovered uninten…

Augustyn(Ann Marie),Agostino(Nicole M),Namey… Breast Cancer Res Treat 2012-09-14

...BRCA2. These cases raise the question of whether or not Single Site BRACAnalysis for a known familial BRCA mutation is a...

Psychological impact of recall on women with BRCA mutations undergoing MRI surv…

Spiegel(Tirtza N),Esplen(Mary Jane),Hill(Kim… Breast 2012-01-27

...BRCA2) completed study instruments at T1 and T2, and 48 at T3. Eighteen women (32%) were recalled for additional imaging...

Pathological characteristics of BRCA-associated breast cancers in Hispanics.

Lagos-Jaramillo(Veronica I),Press(Michael F)… Breast Cancer Res Treat 2012-09-14

...BRCA2 cases. Additional research on the molecular mechanisms involved in the loss of PR in this population is warranted ...

An overview of a recent court challenge to the protection of biomarkers as inte…

Hall(Stephen C),Tromp(Justin M),Jortani(Saee… Clin Chim Acta 2012-08-08

...BRCA2). This decision can affect patent eligibility for inventions related to biomarkers, particularly genetic biomarker...

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