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TP53 BRCA1 CRISPR single-cell cancer

Thompson(Ella R),Gorringe(Kylie L),Choong(Da… Breast Cancer Res Treat 2012-11-23

...BRCA2 mutations and in 1/84 sporadic breast cancer cases. However, the variant was also detected in 2/182 families with ...

Hartman(Anne-Renee),Kaldate(Rajesh R),Sailer… Cancer 2012-07-27

This study assessed BRCA1 and BRCA2 mutation prevalence in an unselected cohort of patients with triple-negative breast ...

Trapp(Oliver),Seeliger(Katharina),Puchta(Hol… Front Plant Sci 2012-08-23

...BRCA2 homologs are important for meiotic DNA recombination. Surprisingly, recent research has revealed that AtBRCA2 also...

Heidemann(Simone),Fischer(Christine),Engel(C… Breast Cancer Res Treat 2012-12-13

Double heterozygosity for disease-causing BRCA1 and BRCA2 mutations is a very rare condition in most populations. Here w...

McBride(David J),Etemadmoghadam(Dariush),Coo… J Pathol 2012-09-25

...BRCA2 mutation showed a high frequency of small chromosomal deletions. These findings indicate that BRCA1/2 germline mut...

Ben Gacem(Riadh),Hachana(Mohamed),Ziadi(Soni… Hum Pathol 2012-11-29

...BRCA2, RASSFA1, TIMP3, CDH1, P16, RARβ2, and DAPK). Overexpression of DNA methyltransferase 1, 3a, and 3b was detected i...

Houdayer(Claude),Caux-Moncoutier(Virginie),K… Hum Mutat 2012-11-28

...BRCA2 splice study to date by testing 272 VUSs (327 analyses) within the BRCA splice network of Unicancer. All these VUS...

Cortesi(Laura),De Nicolo(Arcangela),Medici(V… Breast Cancer Res Treat 2012-11-19

Unambiguous classification of BRCA1 and BRCA2 variants of uncertain significance (VUS) is a challenging task that vexes ...

Ottini(Laura),Silvestri(Valentina),Rizzolo(P… Breast Cancer Res Treat 2012-11-19

...BRCA2 mutations (p=0.016 and 0.001, respectively). In conclusion, our findings indicate that BRCA2-related MBCs represen...

Gonzalez-Hormazabal(Patricio),Reyes(Jose M),… Mol Biol Rep 2012-11-13

Since the discovery of the BRCA1 and BRCA2 genes, much work has been carried out to identify further breast cancer (BC) ...

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