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Earlier age of onset of BRCA mutation-related cancers in subsequent generations.

Litton(Jennifer K),Ready(Kaylene),Chen(Huiqi… Cancer 2012-02-28

...BRCA2 mutations, maternal inheritance, paternal inheritance, breast cancer only, and breast cancer-identified and ovaria...

Quality of life and health status after prophylactic salpingo-oophorectomy in w…

Finch(Amy),Narod(Steven A) Maturitas 2012-03-27

...BRCA2 mutation at age 35 or after childbearing is complete. This procedure is the mainstay of ovarian and fallopian tube...

Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorect…

Cohen(J V),Chiel(L),Boghossian(L),Jones(M),S… Fam Cancer 2012-07-12

...BRCA2 (B1/2) mutations. Despite its clear benefits, little is known about non-cancer endpoints in this population. Medic...

Clinical implications for BRCA gene mutation in breast cancer.

Xu(Jin),Wang(Baosheng),Zhang(Yanjun),Li(Ruih… Mol Biol Rep 2012-05-25

To investigate the mutations of BRCA1 and BRCA2 and determine whether clinic-pathological factors related to BRCA gene m...

A deleterious BRCA1 mutation in a young Pakistani woman with metaplastic breast…

Rashid(Muhammad U),Shah(Mazher A),Azhar(Rafa… Pathol Res Pract 2012-02-09

...BRCA2 genes have been rarely found or described in MBC. We report the identification of the BRCA1 185delAG mutation in a...

Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-de…

Rego(M A),Harney(J A),Mauro(M),Shen(M),Howle… Oncogene 2012-03-26

...BRCA2 function cooperatively in the FA-BRCA pathway to repair damaged DNA. Activation of the FA-BRCA pathway occurs via ...

BRCA1 R71K missense mutation contributes to cancer predisposition by increasing…

Zhang(Liying),Chen(Lishi),Bacares(Ruben),Rug… Breast Cancer Res Treat 2012-03-22

Mutation screening of the breast and ovarian cancer predisposition genes BRCA1 and BRCA2 is becoming an increasingly imp...

Comparative analysis of loss of heterozygosity and expression profile in normal…

Zikan(Michal),Bohm(Jan),Pavlista(David),Cibu… Clin Transl Oncol 2012-01-04

...BRCA2 and p53; and the gene expression of the VEGF gene and Bcl-2 gene. LOH in the BRCA1 gene was present in 44.74% of i...

Prospective study of breast cancer risk for mutation negative women from BRCA1 …

Harvey(S L),Milne(R L),McLachlan(S A),Friedl… Breast Cancer Res Treat 2012-03-22

...BRCA2 mutation carrier from 224 mutation positive (128 BRCA1, 96 BRCA2) families, had no personal cancer history at base...

Characteristics of double heterozygosity for BRCA1 and BRCA2 germline mutations…

Noh(Jae Myoung),Choi(Doo Ho),Nam(Seok Jin),L… Breast Cancer Res Treat 2012-08-21

...BRCA2 mutations, six breast tumors of five patients who carried deleterious mutations in both of the genes were included...

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