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Alterations in oncogenes, tumor suppressor genes, and growth factors associated…

Bast(R C),Mills(G B) Methods Mol Med 2012-10-02

...BRCA2, mismatch repair genes, or p53 (detailed in Subheading 2.2.). Somatic mutations have been found in sporadic ovaria...

A non-BRCA1/2 hereditary breast cancer sub-group defined by aCGH profiling of g…

Didraga(M A),van Beers(E H),Joosse(S A),Bran… Breast Cancer Res Treat 2012-02-08

Germline mutations in BRCA1 and BRCA2 explain approximately 25% of all familial breast cancers. Despite intense efforts ...

Brca2, Rad51 and Mre11: performing balancing acts on replication forks.

Costanzo(Vincenzo) DNA Repair (Amst) 2012-01-30

...BRCA2 play unexpected functions during DNA replication by protecting nascent DNA from Mre11 mediated degradation, which ...

Response to neoadjuvant systemic therapy for breast cancer in BRCA mutation car…

Arun(Banu),Bayraktar(Soley),Liu(Diane D),Gut… J Clin Oncol 2012-01-17

...BRCA2 mutations, respectively. Twenty-six (46%) of 57 BRCA1 carriers achieved a pCR, compared with three (13%) of 23 BRC...

Novel LOVD databases for hereditary breast cancer and colorectal cancer genes i…

Pan(Min),Cong(Peikuan),Wang(Yue),Lin(Changso… Hum Mutat 2012-03-27

...BRCA2, mismatch repair genes (MMR), and APC genes for breast cancer, Lynch syndrome, and familial adenomatous polyposis ...

Cytogenetic polyclonality of breast carcinomas: association with clinico-pathol…

Steinarsdottir(Margret),Gudmundsson(Ingi Hra… Genes Chromosomes Cancer 2012-03-15

...BRCA2 mutation. Less than one third of the polyclonal samples were identified by flow cytometry alone. Cytogenetic chang...

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP c…

Volcic(Meta),Karl(Sabine),Baumann(Bernd),Sal… Nucleic Acids Res 2012-02-27

...BRCA2. Additionally, we provide evidence that NF-κB interacts with CtIP-BRCA1 complexes and promotes BRCA1 stabilization...

Mutual exclusivity analysis identifies oncogenic network modules.

Ciriello(Giovanni),Cerami(Ethan),Sander(Chri… Genome Res 2012-06-13

...BRCA2 is mutually exclusive of amplification of CCNE1 and inactivation of RB1, suggesting distinct alternative causes of...

PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond.

Banerjee(Susana),Kaye(Stan) Curr Oncol Rep 2012-01-05

...BRCA2 genes. Accumulating evidence suggests that PARP inhibitors may have a wider application in the treatment of sporad...

Earlier age of onset of BRCA mutation-related cancers in subsequent generations.

Litton(Jennifer K),Ready(Kaylene),Chen(Huiqi… Cancer 2012-02-28

...BRCA2 mutations, maternal inheritance, paternal inheritance, breast cancer only, and breast cancer-identified and ovaria...

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