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Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorect…

Cohen(J V),Chiel(L),Boghossian(L),Jones(M),S… Fam Cancer 2012-07-12

...BRCA2 (B1/2) mutations. Despite its clear benefits, little is known about non-cancer endpoints in this population. Medic...

Genomic instability in breast and ovarian cancers: translation into clinical pr…

Vollebergh(Marieke A),Jonkers(Jos),Linn(Sabi… Cell Mol Life Sci 2012-03-05

...BRCA2. BRCA-associated breast and ovarian cancers are hallmarked by genomic instability and high sensitivity to DNA doub...

RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumo…

Suwaki(Natsuko),Klare(Kerstin),Tarsounas(Mad… Semin Cell Dev Biol 2012-06-04

...BRCA2 tumour suppressor, through the recently reported links between RAD51 paralog deficiencies and tumorigenesis trigge...

Identification of germline alterations of the mad homology 2 domain of SMAD3 an…

Tram(Eric),Ibrahim-Zada(Irada),Briollais(Lau… Breast Cancer Res 2012-08-21

...BRCA2 breast cancer cases and 710 population controls recruited by the Ontario site of the breast cancer family registry...

Molecular and clinical characterization of an in frame deletion of uncertain cl…

Rath(Michelle G),Fathali-Zadeh(Farnoosh),Lan… Breast Cancer Res Treat 2012-09-28

In this study, we analyzed a "variant of uncertain significance" (VUS) located in exon 23 of the BRCA2 gene exhibited by...

Methylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter gene in t…

Fumagalli(Caterina),Pruneri(Giancarlo),Possa… Breast Cancer Res Treat 2012-11-19

...BRCA2 mutational status was known. We evaluated MGMT methylation status by methylation-specific PCR (MSP) in formalin-fi...

Long-term follow-up of Jewish women with a BRCA1 and BRCA2 mutation who underwe…

Metcalfe(Kelly A),Mian(Nida),Enmore(Melissa)… Breast Cancer Res Treat 2012-09-28

...BRCA2, which are present in up to 2.5% of Jewish women. Population genetic testing for Jewish women has been proposed; h...

Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast can…

Bosviel(Rémy),Durif(Julie),Déchelotte(Pierre… Br J Nutr 2012-12-10

...BRCA2) and oncosuppressors in breast cancer cell lines (MDA-MB-231 and MCF-7) and in a dystrophic breast cell line (MCF-...

Spectra of BRCA1 and BRCA2 mutations in Korean patients with breast cancer: the…

Jang(Ja-Hyun),Lee(Jeong Eon),Kwon(Min-Jung),… J Hum Genet 2012-07-17

...BRCA2 genes vary among populations. In the present study, the mutation spectra of the BRCA1/BRCA2 genes in Korean breast...

Breast cancer risk in relation to alcohol consumption and BRCA gene mutations--…

Dennis(Jessica),Krewski(Daniel),Côté(Frédéri… Breast J 2012-02-01

The variable penetrance of the BRCA1 and BRCA2 genes suggests that other genetic or environmental factors may interact w...

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