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TP53 BRCA1 CRISPR single-cell cancer

Tischkowitz(Marc),Winqvist(Robert) J Pathol 2011-08-24

...BRCA2 and FANCN/PALB2, also predispose to breast cancer in heterozygote carriers. The FA genes code for proteins that ac...

Krawczyk(Przemek M),Eppink(Berina),Essers(Je… Proc Natl Acad Sci U S A 2011-09-29

Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ri...

Ochiai(Kazuhiko),Yoshikawa(Yasunaga),Yoshima… FEBS Lett 2011-09-05

...BRCA2 is essential for recombinational DNA repair. BRCA2 specifically binds to RAD51 via eight BRC repeat motifs and del...

Schlacher(Katharina),Christ(Nicole),Siaud(Ni… Cell 2011-07-22

...BRCA2 but are stable in wild-type cells. BRCA2 mutational analysis reveals that a conserved C-terminal site involved in ...

Schousboe(John T),Kerlikowske(Karla),Loh(And… Ann Intern Med 2011-09-06

...BRCA2 mutations.,Mammography screening should be personalized on the basis of a woman's age, breast density, history of ...

Vral(A),Willems(P),Claes(K),Poppe(B),Perlett… Mol Med Rep 2011-11-01

...BRCA2. Combined risk genotype analysis revealed that Rad51 SNPs enhance BC risk in BRCA2 patients, whereas Xrcc3 SNPs si...

Johnson(Neil),Li(Yu-Chen),Walton(Zandra E),C… Nat Med 2011-09-20

...BRCA2, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). However, BRCA-deficient tumors represent ...

Vuorela(Mikko),Pylkäs(Katri),Winqvist(Robert) BMC Med Genet 2011-10-03

...BRCA2 explain less than 25% of familial aggregation of breast cancer, which suggests the involvement of additional susce...

Stegel(Vida),Krajc(Mateja),Zgajnar(Janez),Te… BMC Med Genet 2011-03-03

...BRCA2 and 0% for BRCA1.,among the mutations detected in Slovenian population, 5 mutations in BRCA1 and 4 mutations in BR...

Metcalfe(Kelly),Lynch(Henry T),Ghadirian(Par… Breast Cancer Res Treat 2011-08-01

Women with a BRCA1 or BRCA2 mutation have an elevated risk of breast cancer and of contralateral breast cancer. In this ...

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