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Double heterozygosity in the BRCA1 and BRCA2 genes in the Jewish population.

Lavie(O),Narod(S),Lejbkowicz(F),Dishon(S),Go… Ann Oncol 2011-09-23

...BRCA2 genes are not established.,Data were collected from the database of Clalit Health Services National Familial Cance...

Indicators of homologous recombination deficiency in breast cancer and associat…

Lips(E H),Mulder(L),Hannemann(J),Laddach(N),… Ann Oncol 2011-09-23

...BRCA2-like aCGH pattern and the amplification of the BRCA2 inhibiting gene EMSY were frequently observed (43% and 13%, r...

Somatic structural rearrangements in genetically engineered mouse mammary tumor…

Varela(Ignacio),Klijn(Christiaan),Stephens(P… Genome Biol 2011-06-02

...Brca2-associated hereditary breast cancer, and E-cadherin (Cdh1) mutated lobular breast cancer.,We show that although Br...

Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.

Ding(Yuan Chun),Steele(Linda),Kuan(Chih-Jen)… Breast Cancer Res Treat 2011-07-15

...BRCA2 gene, followed by direct sequencing of the PALB2 gene in BRCA2-negative MBC cases. Pathogenic BRCA2 mutations were...

Association of the variants CASP8 D302H and CASP10 V410I with breast and ovaria…

Engel(Christoph),Versmold(Beatrix),Wappensch… Cancer Epidemiol Biomarkers P… 2011-02-22

...BRCA2 mutation carriers.,CASP8 D302H decreases breast and ovarian cancer risk for BRCA1 mutation carriers but not for BR...

BRCA mutations in the management of breast cancer: the state of the art.

Narod(Steven A) Nat Rev Clin Oncol 2011-05-04

Genetic testing for BRCA1 and BRCA2 mutations is gaining acceptance in clinical oncology worldwide and may help target u...

Risk-reducing strategies for women carrying BRCA1/2 mutations with a focus on p…

Salhab(Mohamed),Bismohun(Selina),Mokbel(Kefa… BMC Womens Health 2011-02-25

Women who have inherited mutations in the BRCA1 or BRCA2 genes have substantially elevated risks of breast and ovarian c...

Breast cancer surgery trend changes since the introduction of BRCA1/2 mutation …

Mislowsky(Angela),Domchek(Susan),Stroede(Cec… Ann Surg Oncol 2011-06-09

...BRCA2 mutation carriers diagnosed with unilateral breast cancer between 1963 and 2009. Mutation carriers with ovarian ca...

Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through hom…

Akamatsu(Yufuko),Jasin(Maria) PLoS Genet 2011-03-07

...BRCA2. Swi5(-/-) and Sfr1(-/-) cells are selectively sensitive to agents that cause DNA strand breaks, in particular ion...

The effects of parity, breastfeeding, and infertility treatment on the risk of …

Fishman(Ami) Int J Gynecol Cancer 2011-03-04

...BRCA2 mutation carriers is important and should be a crucial part of genetic counseling. The discussion of parity and cl...

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