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Personalizing cancer treatment in the age of global genomic analyses: PALB2 gen…

Villarroel(Maria C),Rajeshkumar(N V),Garrido… Mol Cancer Ther 2011-07-28

...BRCA2 interactions critical to DNA double-strand break repair. This work suggests that inactivation of the PALB2 gene is...

Association of a LSP1 gene rs3817198T>C polymorphism with breast cancer risk: e…

Chen(Min-Bin),Li(Chen),Shen(Wen-Xiang),Guo(Y… Mol Biol Rep 2011-12-27

...BRCA2 mutation carriers in the allele contrast (OR = 1.11, 95% CI = 1.03-1.20), the homozygote codominant (OR = 1.23, 95...

Identification and Management of Women With BRCA Mutations or Hereditary Predis…

Pruthi(Sandhya),Gostout(Bobbie S),Lindor(Nor… Mayo Clin Proc 2011-01-18

Women with a germline BRCA1 or BRCA2 mutation or a hereditary predisposition for breast and ovarian cancer have substant...

Recruitment of black women for a study of inherited breast cancer using a cance…

Pal(Tuya),Rocchio(Erin),Garcia(Ana),Rivers(D… Genet Test Mol Biomarkers 2011-07-19

...BRCA2 genes.,State mandated recruitment methods included TWO mailings, followed by a telephone response card for patient...

BRCA germline mutations in women with uterine serous carcinoma--still a debate.

Lavie(Ofer),Ben-Arie(Alon),Segev(Yakir),Faro… Int J Gynecol Cancer 2011-06-02

...BRCA2 mutations in an enlarged series of uterine serous carcinoma (USC) patients and to determine whether patients with ...

Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: do…

Kim(Ki-Yon),Park(Dong Wook),Jeung(Eui-Bae),C… J Vet Sci 2011-04-28

...brca2/p53. However, the proliferative effect of the ovarian cells was not observed in concurrent brca1/brca2 or p53 knoc...

Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carrie…

Walker(Logan C),Fredericksen(Zachary S),Wang… Breast Cancer Res 2011-09-12

...BRCA2, may contribute to increased risk of breast cancer in BRCA2 mutation carriers. This finding suggests that genes wi...

Hepatoblastoma in a 4-year-old girl with Fanconi anaemia.

Kopic(Sascha),Eirich(Katharina),Schuster(Bea… Acta Paediatr 2011-07-14

...BRCA2 gene.,We describe the first case of hepatoblastoma in a patient with FA to raise awareness of this tumour type in ...

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor l…

Patel(Anand G),Sarkaria(Jann N),Kaufmann(Sco… Proc Natl Acad Sci U S A 2011-05-06

...BRCA2, BRCA1, or ATM. Collectively, our results not only implicate PARP1 catalytic activity in the regulation of NHEJ in...

Adamantanyl-histone deacetylase inhibitor H6CAHA exhibits favorable pharmacokin…

Konsoula(Zacharoula),Cao(Hong),Velena(Alfred… Int J Radiat Oncol Biol Phys 2011-05-12

...BRCA2). Combined modality of H6CAHA (daily intraperitoneal injections for 10 days) with γ-radiation (10 × 2 Gy) complete...

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