...BRCA2 in 5(10.9%), and non-BRCA HRD + in 11(23.9%). Olaparib was given to 27(58.7%) and Rucaparib to 19(41.3%). At a med...
...BRCA2, PALB2, CHEK2, and ATM, while in CRC patients PVs were enriched in MLH1, MUTYH, MSH2, and CHEK2. Notably, CHEK2 wa...
...BRCA2 NM_000059.3:c.439C>A, were identified in the Chinese population. These findings provide a biological rationale to ...
...BRCA2-mutated mCRPC who achieved a sustained complete response to olaparib monotherapy. After progression on androgen de...
...BRCA2 PV carriers (n = 8) and BRCA2 wild-type patients (n = 59). Furthermore, two BRCA2-deficient ER-positive/HER2-negat...
...BRCA2, RAD50, RAD51, Ku70, Ku80, XRCC1, and XRCC4.ASX inhibited the overexpression of many genes and enhanced the activi...
...BRCA2/ATM/CDKN2A/STK11/PALB2/TP53, as well as mismatch repair genes, confer a substantially higher lifetime risk, while ...
...BRCA2 genes disrupt homologous recombination repair pathways, creating a therapeutic vulnerability that can be exploited...
...BRCA2, were associated with increased CBS mutation enrichment following radiotherapy. Together, these findings indicate ...
...BRCA2 (gBRCA2) alterations predispose tumors toward loss-of-function alterations in RB1, a key mechanism of tumor escape...
山东省济南市章丘区文博路2号
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