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TP53 BRCA1 CRISPR single-cell cancer

Smith(Joanne),Tho(Lye Mun),Xu(Naihan),Gilles… Adv Cancer Res 2011-02-18

...BRCA2, but at the cost of genomic instability and cancer predisposition. By contrast, the ATR-Chk1 pathway is the princi...

Nathanson(Katherine L),Domchek(Susan M) Annu Rev Med 2011-05-17

...BRCA2. Screening techniques, such as breast magnetic resonance imaging, enable early detection of cancers in high-risk w...

Ginsburg(O M),Dinh(N V),To(T V),Quang(L H),L… Clin Genet 2011-09-28

...BRCA2 using the protein truncation test and by allele-specific testing for 17 founder mutations which have been reported...

Moon(Young Jin),Brazeau(Daniel A),Morris(Mar… Evid Based Complement Alterna… 2011-07-14

...BRCA2), cAMP responsive element binding protein 2 (ATF-2), interleukin 2 (IL-2), heat shock 27 KD protein (hsp27), and C...

Laitman(Yael),Borsthein(Roni Tsipora),Stoppa… Breast Cancer Res Treat 2011-08-16

Three mutations in BRCA1 (185delAG, 5382InsC) and BRCA2 (6174delT) predominate among high risk breast ovarian cancer Ash...

Slater(E P),Langer(P),Niemczyk(E),Strauch(K)… Clin Genet 2011-02-17

...BRCA2 mutation. We identified three (3.7%) truncating PALB2 mutations, each producing different stop codons: R414X, 508-...

Kleibl(Zdenek),Havranek(Ondrej),Kormunda(Sta… J Cancer Res Clin Oncol 2011-04-27

...BRCA2 gene (HR = 3.50; 95% CI 1.25-9.78; P = 0.017).,Our results confirm that AIB1 poly-Q repeat length polymorphism doe...

Tamboom(Kristiina),Kaasik(Krista),Arsavskaja… Hered Cancer Clin Pract 2011-07-14

The aim of this study was to identify BRCA1 and BRCA2 mutations in the Estonian population. We analyzed genetic data and...

Domchek(Susan M),Friebel(Tara M),Garber(Judy… Breast Cancer Res Treat 2011-01-31

...BRCA2 (BRCA1/2) mutation carriers. Occult ovarian/fallopian tube cancers (OOC) detected at the time of RRSO have been re...

Lasa(A),Ramón y Cajal(T),Llort(G),Suela(J),C… Breast Cancer Res Treat 2011-01-14

...BRCA2 genes confer a high risk of breast and ovarian cancer but the incomplete penetrance of these mutations suggests th...

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