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The DNA helicase HELQ promotes replication fork reversal in coordination with...

Dunbayev(Y),Chen(YJ),Sassi(L),Lee(EA),Ra(J... Nucleic Acids Res 2026-04-23

...BRCA2- or FANCD2-dependent fork protection is lost. Mechanistically, biochemical reconstitution shows that HELQ is stimu...

Uterine serous carcinoma and germline genetic testing: patterns of referral, ...

Tostrud(L),Turkmen(SB),Zhang(J),Hodan(R),K... J Med Genet 2026-07-23

...BRCA2, BRIP1, CHEK2, MSH6, PMS2 and ATM. Only a personal history of cancer other than USC was independently associated w...

Contemporary risk assessment and risk-reducing strategies for tubo-ovarian ca...

Viveros-Carreño(D),Beshar(I),Agustí(N),Mur... Int J Gynecol Cancer 2026-06-00

...BRCA2 pathogenic variants. While risk-reducing salpingo-oophorectomy remains the standard for prevention, conferring red...

Absence of high-risk human papillomavirus in breast cancer tissues from young...

Kaya(E),Kahraman(E),Arikan(AE),Tokat(F),Ur... BMC Womens Health 2026-04-29

...BRCA2 mutations. This retrospective, single-center study included women younger than 50 years with confirmed BRCA1/BRCA2...

Immediate protective effect of rUCMSC-EVs on ovarian function in a cyclophosp...

Yang(Z),Zou(C),Deng(Y),Xiao(H),Zou(Y),Wang... J Ovarian Res 2026-04-29

...BRCA2, MRE11 and RAD51). Our study demonstrates that the combined intervention of rUCMSC-EVs and chemotherapy drugs can ...

The contribution of rare germline variants to the immune landscape of breast ...

Rojas-Rodríguez(F),Canisius(S),Keeman(R),B... Genome Med 2026-05-09

...BRCA2, PALB2, RAD51D, and MSH6 were associated with a 1.3 to twofold abundance of CD163-positive cells. Estrogen recepto...

Comparative oncology of male and female breast cancer: diagnostic paradigms a...

Das(J),Bhui(U),Chakraborty(GS),Mazumder(D)... J Basic Clin Physiol Pharmacol 2026-05-01

...BRCA2 mutations and the hormonal imbalance. The management approach, such as surgery, chemotherapy, radiotherapy, and ho...

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.

Li(J),Petersen(KV),Ummethum(H),Bagge(J),Hi... Nucleic Acids Res 2026-05-05

...BRCA2 depleted cells are highly dependent on TOPBP1-PLK1 complex formation. Altogether, we reveal the molecular details ...

Clinical variant interpretation comparing two saturation genome editing-based...

Shin(JH),Park(KS),Kim(YG),Jang(MA),Jang(JH... Front Genet None

Two saturation genome editing (SGE) studies for BRCA2 using haploid human HAP1 cells and mouse embryonic stem cells, res...

Real-world genetic testing data of ovarian cancer patients: Informing counsel...

Shachar(E),Rotkop(G),Haas(R),Frankenthal(R... Gynecol Oncol 2026-06-00

...BRCA2 exceeded BRCA1 in patients ≥70. Moderate-penetrance variants (BRIP1,PALB2) were relatively enriched, while ATM and...

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