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Genomic analysis of oesophageal carcinoma (EC) identifies recurrent mutations...

Wang(J),Xiu(J),Battaglin(F),Arai(H),Soni(S... Oncogene 2026-09-00

...BRCA1 (11.5% vs 1%, all q < 0.05), compared to KMT2-wildtype (WT) tumors. Meanwhile, no significant mutational differenc...

Lights genes action: Video strategy for BRCA1/2 patient education.

Karimaghaie(T),Fasano(G),Lopez(S),Min(S),K... Gynecol Oncol Rep 2026-08-00

...BRCA1 and BRCA2 ( BRCA1/2) genes increase lifetime risk of several cancers including breast and ovarian. Communicating c...

The real-world utility of homologous repair deficiency testing in BRCA1/2 wil...

Maradiya(R),Kinloch(M),De Leo(A),de Biase(... Gynecol Oncol 2026-08-00

...BRCA1/2 wild-type (BRCA-wt) tumors. The main cohort included patients with HGSC in Alberta, Canada who underwent HRD tes...

Uptake of breast cancer risk-management strategies among unaffected BRCA 1/2 ...

Godino(L),Innella(G),Di Palo(C),Bono(GR),T... Eur J Surg Oncol 2026-09-00

Women carrying BRCA1/BRCA2 pathogenic variants face a substantially increased risk of breast cancer and may choose betwe...

Iron-catalyzed oxidative stress reveals an exposome-related ferroptosis-resis...

Kong(Y),Shiraki(Y),Furuhashi(K),Maruyama(S... Redox Biol 2026-09-00

...Brca1(L63X/+) rats. Ferric nitrilotriacetate exposure induced dynamic remodeling of proximal tubular epithelium, charact...

BRCA1/2 variant landscape and clinical correlates in high-risk breast cancer ...

Gu(W),Khan(NU),Lei(H),Fu(J),Xu(C),Chen(X),... Front Oncol None

...BRCA1 and BRCA2 (BRCA1/2) variant landscape specifically in high-risk, clinically referred populations remains poorly ch...

Discovery of CTX-439: A Potent and Selective CDK12 Inhibitor as a Prospective...

Shimokawa(K),Ono(K),Asano(M),Hirayama(T),T... ACS Med Chem Lett 2026-07-09

...BRCA1 and BRCA2, which are essential in maintaining genomic stability. In this study, we describe the lead optimization ...

Prophylactic nipple-sparing mastectomy and immediate breast reconstruction in...

Fu(F),Chu(F),Wan(Q),Zhang(Y),Xie(Y) Gland Surg 2026-06-30

...BRCA1/2 pathogenic variants (PVs). Unlike Western BRCA1/2 carriers, data regarding this procedure for Chinese healthy wo...

Chk1 inhibition emerges as the most effective partner for PARP inhibition in ...

Morimoto(Y),Musha(Y),Takeuchi(O),Inano(H),... Discov Oncol 2026-07-14

...BRCA1/2 wild-type MIA PaCa-2 and BxPC-3 cells, whereas the effect was minimal in BRCA2-deficient Capan-1 cells. Compared...

Folate receptor alpha, TROP2 and HER2 in high-grade serous ovarian cancer: Ex...

Zhao(CL),Wang(XP),Wei(K),Ge(YJ),Sun(PL) Gynecol Oncol 2026-08-00

...BRCA1/2 mutations and/or a Genomic Scar Score (GSS) ≥45. Clinicopathological correlations and survival outcomes were eva...

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