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Functional assays for BRCA1 and BRCA2 variant analysis: new tools and their a...

Bose(M),Faseela(EE),Rossing(M),Sørensen(CS... NPJ Breast Cancer 2026-04-15

...BRCA2 function are linked to hereditary breast and ovarian cancers. As BRCA1 and BRCA2 are critical for homologous recom...

Invasive ductal and lobular carcinoma and receptor status in the genetic cont...

Al-Masri(M),Alayyan(O),Safi(Y) Sci Rep 2026-04-15

...BRCA2, CDH1, CHEK2, EPCAM, PALB2, and PMS2 are more strongly associated with ILC - to varying degrees. [p < 0.001]. Addi...

Importance of genetic testing in childhood cancer survivors for hereditary ca...

Urbas(A),Ušaj(P),Šeruga(B),Krajc(M),Hotuje... Hered Cancer Clin Pract 2026-04-15

...BRCA2 genes. In 61.9% (13/21) of positive cases, an identified cancer predisposition syndrome was linked to the childhoo...

Fertility desires and outcomes in patients with selected hereditary cancer sy...

Connelly(EA),Lowry(CM),Camara(C),Wei(J),Ga... Gynecol Oncol Rep 2026-06-00

...BRCA2, MLH1, and MSH2 mutations. This was a multi-site, retrospective cohort study including women aged 21-45 years old ...

Nationwide genomic data analysis of central nervous system tumors in Japan ba...

Kawauchi(D),Ohno(M),Takahashi(M),Koyama(T)... Int J Clin Oncol 2026-07-00

...BRCA2, and MSH6. FoundationOne® CDx exhibits greater number of mutations, copy number alterations, and generating therap...

Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates a...

Gürel(Ç),Tut(E),Kuşçu(GC),Buhur(A),Germiya... J Drug Target 2026-05-07

...BRCA2-containing complex 3 (BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study ...

Homologous recombination-deficient high-grade serous ovarian cancers exhibit ...

Hanna(K),Levin(G),Al Nasir(M),Lacouline-Bo... Int J Gynecol Cancer 2026-04-09

...BRCA2mut, 15 (18.5%) tumors had no BRCA1 or BRCA2 mutations but exhibited a genomic instability score ≥42 and were class...

Genomic characterization of DNA damage response pathway mutations reveals the...

Yang(L),Cheng(J),Guo(X),Xiao(H),Kuang(X),Y... Respir Res 2026-05-06

...BRCA2 (> 5%), and pathways including the Fanconi anemia (FA), homologous recombination repair (HRR), and mismatch repair...

Video Education With Clinical Genetic Testing Coordinators for the Rapid Eval...

Stopfer(JE),Horiguchi(M),Chittenden(A),Tso... JCO Oncol Pract 2026-05-07

...BRCA2, BRCA1, and CHEK2 being the most frequently identified. Disparities in testing completion were observed, with olde...

In vivo genetic circuit drives systemic PARP1 siRNA assembly into small extra...

Javed(A),Ur-Rehman(U),Yuan(R),Chen(X),Guo(... J Control Release 2026-07-10

...BRCA2-deficient model (E0771) and an immunodeficient BRCA2-mutant xenograft model (HCC1599). The plasmid was predominant...

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