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Linking the cellular functions of BRCA genes to cancer pathogenesis and treatme…

Venkitaraman(Ashok R) Annu Rev Pathol 2009-05-28

...BRCA2 arises from the distinct functions served by their products in DNA repair or mitosis, explains many features of ca...

The c.156_157insAlu BRCA2 rearrangement accounts for more than one-fourth of de…

Peixoto(Ana),Santos(Catarina),Rocha(Patrícia… Breast Cancer Res Treat 2009-02-17

...BRCA2 mutation in 14 families and showed that it accounts for more that one-fourth of deleterious BRCA1/BRCA2 mutations ...

Hereditary breast/ovarian cancer: clinicopathological characteristics and survi…

Syamala(Vani),Syamala(Volga S),Sreeja(Leelak… J Exp Ther Oncol 2009-01-15

...BRCA2 status, 19 were BRCA2 mutation positive. In survival analysis, BRCA2 gene mutation status (P = 0.02) and clinicopa...

Epitopic peptides with low similarity to the host proteome: towards biological …

Kanduc(Darja) Expert Opin Biol Ther 2009-01-13

...BRCA2 protein as a model, the principle of sequence uniqueness is defined as the rationale for a pharmacological platfor...

Familial pancreatic cancer: from genes to improved patient care.

Hruban(Ralph H),Klein(Alison P),Eshleman(Jam… Expert Rev Gastroenterol Hepa… 2009-03-05

...BRCA2, p16/CDKN2A, STK11 and PRSS1. Individuals can be tested for germline mutations in these genes; however, until rece...

Development and pilot testing of a decision aid for men considering genetic tes…

Juan(Anne S),Wakefield(Claire E),Kasparian(N… Genet Test 2009-03-03

...BRCA2 gene. All men who reviewed the decision aid indicated that they would recommend the booklet to other men in the sa...

[BRCA1/2 gene mutation in Chinese familial breast cancer patients: a multi-cent…

Hu(Zhen),Li(Wen-Feng),Liu(Xiao-Yi),Zhang(Bin… Zhonghua Yi Xue Za Zhi 2009-05-20

...BRCA2) were found in the 115 breast cancer specimens with an overall mutation rate of 12.2%. After stratification with n...

Advances in breast cancer: pathways to personalized medicine.

Olopade(Olufunmilayo I),Grushko(Tatyana A),N… Clin Cancer Res 2009-01-06

...BRCA2 genes increase the risk of breast and ovarian cancers has radically transformed our understanding of the genetic b...

Breast cancer risks in women with a family history of breast or ovarian cancer …

Metcalfe(K A),Finch(A),Poll(A),Horsman(D),Ki… Br J Cancer 2009-03-10

Genetic testing for mutations in BRCA1 and BRCA2 is available in Canada for women with a significant family history of b...

The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and com…

Titus(Tom A),Yan(Yi-Lin),Wilson(Catherine),S… Mutat Res 2009-09-29

...brca2) in both conditions.

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