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ATM and Artemis promote homologous recombination of radiation-induced DNA doubl…

Beucher(Andrea),Birraux(Julie),Tchouandong(L… EMBO J 2009-11-30

...Brca2, Rad51 and Rad54, repair of radiation-induced DSBs by HR in G2 also involves Artemis and ATM suggesting that they ...

Electronic health records and the management of women at high risk of hereditar…

Drohan(Brian),Ozanne(Elissa M),Hughes(Kevin … Breast J 2009-12-08

...BRCA2 mutation. Unfortunately, the task of identifying these patients at high risk is a daunting challenge. This problem...

Influence of race/ethnicity on genetic counseling and testing for hereditary br…

Forman(Andrea D),Hall(Michael J) Breast J 2009-12-08

...BRCA2 (BRCA1/2) has become an integral element of comprehensive patient evaluation and cancer risk management in the Uni...

Early-stage BRCA2-linked breast cancer diagnosed in the first trimester of preg…

Diamond(Jennifer R),Finlayson(Christina A),T… Oncology (Williston Park) 2009-10-16

...BRCA2 gene mutation. She underwent lumpectomy and axillary lymph node dissection without any evidence of lymph node meta...

Breast Cancer Risk Reduction Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2009-11-09

...BRCA2 mutations, the risk of future breast cancer is very high, and the performance of a bilateral prophylactic mastecto...

Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad5…

Gildemeister(Otto S),Sage(Jay M),Knight(Kend… J Biol Chem 2009-12-24

...Brca2-defective cell line Capan-1. To address a possible Brca2-independent mechanism for Rad51 nuclear transport, we ana...

Breast cancer in a BRCA2 mutation carrier with a history of prostate cancer.

Panchal(Seema),Shachar(Orli),O'Malley(France… Nat Rev Clin Oncol 2009-12-14

...BRCA2 germline testing and was found to be a mutation carrier. Following post-test counseling, he was offered clinical b...

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and…

Zhang(Fan),Fan(Qiang),Ren(Keqin),Andreassen(… Mol Cancer Res 2009-12-03

...BRCA2 has been established. We show here that PALB2 physically and functionally connects BRCA1 and BRCA2 into a DNA dama...

Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicent…

Rebbeck(Timothy R),Mitra(Nandita),Domchek(Su… Cancer Res 2009-09-25

...BRCA2 mutation carriers was used to evaluate haplotypes at ATM, BARD1, BRIP1, CTIP, MRE11, NBS1, RAD50, RAD51, and TOPBP...

Altered expression of proliferation-inducing and proliferation-inhibiting genes…

Saleh(Ekram M),El-Awady(Raafat A),Abdel Alim… Cell Biochem Biophys 2009-12-14

...BRCA2 in both cell lines. Conclusively, after validation in clinical samples, overexpression of genes like BRCA1, p53, p...

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