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Drug resistance caused by reversion mutation.

Ashworth(Alan) Cancer Res 2009-01-15

...BRCA2. Furthermore, a similar mechanism seems to be associated with carboplatin resistance in some BRCA2 mutation carrie...

IGF signaling pathway as a selective target of familial breast cancer therapy.

Shukla(Vivek),Coumoul(Xavier),Vassilopoulos(… Curr Mol Med 2009-02-04

...BRCA2). Recent studies have demonstrated a link between the insulin-like growth factor (IGF) signaling pathway and famil...

Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and…

Sangha(Navneet),Wu(Rong),Kuick(Rork),Powers(… Neoplasia 2009-04-24

...Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but freq...

Clinical implications of low-penetrance breast cancer susceptibility alleles.

Freisinger(Francis),Domchek(Susan M) Curr Oncol Rep 2009-03-26

...BRCA2. In the past several years, several low- and moderate-risk breast cancer susceptibility alleles have been identifi...

Breast cancer susceptibility: current knowledge and implications for genetic co…

Ripperger(Tim),Gadzicki(Dorothea),Meindl(Alf… Eur J Hum Genet 2009-09-01

...BRCA2 mutation carriers as well as the risk for breast cancer in certain rare syndromes caused by mutations in TP53, STK...

Breast cancer risks in women with a family history of breast or ovarian cancer …

Metcalfe(K A),Finch(A),Poll(A),Horsman(D),Ki… Br J Cancer 2009-03-10

Genetic testing for mutations in BRCA1 and BRCA2 is available in Canada for women with a significant family history of b...

[BRCA1/2 gene mutation in Chinese familial breast cancer patients: a multi-cent…

Hu(Zhen),Li(Wen-Feng),Liu(Xiao-Yi),Zhang(Bin… Zhonghua Yi Xue Za Zhi 2009-05-20

...BRCA2) were found in the 115 breast cancer specimens with an overall mutation rate of 12.2%. After stratification with n...

Advances in breast cancer: pathways to personalized medicine.

Olopade(Olufunmilayo I),Grushko(Tatyana A),N… Clin Cancer Res 2009-01-06

...BRCA2 genes increase the risk of breast and ovarian cancers has radically transformed our understanding of the genetic b...

No evidence that GATA3 rs570613 SNP modifies breast cancer risk.

Johnatty(Sharon E),Couch(Fergus J),Frederick… Breast Cancer Res Treat 2009-11-17

...BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). We found no association between thi...

Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adher…

Pérez Segura(Pedro),Jiménez(Paula),Olivera(H… Clin Transl Oncol 2009-01-07

...BRCA2 mutation in a referential genetic counselling unit in Spain.,Between January 1998 and November 2006, a total of 68...

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