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Randomized trial of a decision aid for BRCA1/BRCA2 mutation carriers: impact on…

Schwartz(Marc D),Valdimarsdottir(Heiddis B),… Health Psychol 2009-03-26

...BRCA2 mutation carriers must make the difficult decision whether or not to opt for risk reducing mastectomy. To help BRC...

The potential role and application of PARP inhibitors in cancer treatment.

Chalmers(Anthony J) Br Med Bull 2009-10-05

...BRCA2-deficient cancers, and in combination they increase the cytotoxic effects of certain chemotherapy agents.,In order...

Estimated risk of radiation-induced breast cancer from mammographic screening f…

Berrington de Gonzalez(Amy),Berg(Christine D… J Natl Cancer Inst 2009-03-06

...BRCA2 mutation carriers. If we assume that the mortality reduction from mammography is 15%-25% or less for young women, ...

Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mamm…

Klopfleisch(R),Gruber(A D) Vet Pathol 2009-07-10

...BRCA2, and RAD51 mRNA expression was quantified in highly defined laser microdissected tissue samples of simple adenomas...

Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora …

Ryser(Stephan),Dizin(Eva),Jefford(Charles Ed… Cancer Res 2009-03-23

...BRCA2. We used selective small interfering RNAs to distinguish the functions of FL BARD1 and BARD1beta. Depletion of FL ...

High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast ca…

Arun(Banu),Vogel(Kristen J),Lopez(Adriana),H… Cancer Prev Res (Phila) 2009-03-31

Mutations in BRCA1 and BRCA2 increase a woman's lifetime risk of developing breast cancer by 43% to 84%. It was original...

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

McCabe(N),Cerone(M A),Ohishi(T),Seimiya(H),L… Oncogene 2009-04-01

The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutation...

DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site f…

Zhou(Qingwen),Kojic(Milorad),Holloman(Willia… J Biol Chem 2009-05-26

...BRCA2 homolog in Ustilago maydis, is highly conserved and aligns with the DSS1/DNA-binding domain (DBD) of mammalian BRC...

BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews.

Raskin(Leon),Lejbkowicz(Flavio),Barnett-Grin… Cancer Epidemiol Biomarkers P… 2009-06-25

...BRCA2 carriers or noncarriers of any age. A similar magnitude suggestive association, although nonstatistically signific...

LKB1 catalytic activity contributes to estrogen receptor alpha signaling.

Nath-Sain(Suchita),Marignani(Paola A) Mol Biol Cell 2009-10-27

...BRCA2. In this study, we investigate the role of LKB1 in estrogen receptor alpha (ERalpha) signaling. We demonstrate for...

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