Germline mutations of the BRCA1 and BRCA2 genes confer a high life-time risk of ovarian cancer. They represent the most ...
BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian cancers and comprise 10% of total case...
...BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian...
...BRCA2 carriers or noncarriers of any age. A similar magnitude suggestive association, although nonstatistically signific...
...BRCA2-deficient cells are sensitive to As[III] and we suggest that As[III] could be exploited as a therapy for HR-defici...
...BRCA2 mutation.,We enrolled and treated 60 patients; 22 were carriers of a BRCA1 or BRCA2 mutation and 1 had a strong fa...
...BRCA2 and regulates the localization of BRCA2 and Rad51 at sites of DNA damage. The interaction occurs through the NH(2)...
...BRCA2) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that other suscepti...
...BRCA2, CHEK2 genes, which arise on preinvasive stage in sporadic pancreatic adenocarcinomas (PA), in Russian patients. W...
...BRCA2 (p.E462G p.Y2660D, p.R2784Q, p.R3052W and p.R3052Q). Likelihood ratios varied from 0.097 (BRCA2, p.E462G) to 230.6...
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