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Impaired removal of DNA interstrand cross-link in Nijmegen breakage syndrome an…

Tsuchida(Ken),Komatsu(Kenshi) Cancer Sci 2009-01-23

...BRCA2 protein displayed normal ICL removal, although they were compromised with respect to recombination. This normal IC...

BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast…

Ottini(Laura),Rizzolo(Piera),Zanna(Ines),Fal… Breast Cancer Res Treat 2009-09-29

...BRCA2 mutations. The same BRCA1 mutation (3347delAG) was detected in two unrelated MBC cases. Three novel BRCA2 pathogen...

Performance of prediction models for BRCA mutation carriage in three racial/eth…

Kurian(Allison W),Gong(Gail D),John(Esther M… Cancer Epidemiol Biomarkers P… 2009-06-16

...BRCA2. Accurate carrier prediction models are needed to target costly testing. Two widely used models, BRCAPRO and BOADI...

High incidence of protein-truncating TP53 mutations in BRCA1-related breast can…

Holstege(Henne),Joosse(Simon A),van Oostrom(… Cancer Res 2009-06-19

...BRCA2 function. Previous research has found a strong correlation between BRCA mutation and TP53 mutation. However, TP53 ...

PARP inhibitors: new partners in the therapy of cancer and inflammatory disease…

Peralta-Leal(Andreína),Rodríguez-Vargas(José… Free Radic Biol Med 2009-12-17

...BRCA2). PARP becomes activated in response to oxidative DNA damage and depletes cellular energy pools, thus leading to c...

Regulatory aspects of genetic research with residual human tissue: effective an…

Schmidt(Marjanka K),Vermeulen(Eric),Tollenaa… Eur J Cancer 2009-09-15

...BRCA2 germline mutations were analysed in DNA isolated from residual paraffin-embedded tissue samples. Because it was no...

Prolonged survival in a patient with BRCA2 associated metastatic pancreatic can…

James(Edward),Waldron-Lynch(Maeve G),Saif(Mu… Anticancer Drugs 2009-09-11

...BRCA2 associated pancreatic cancer. This case shows that patients with metastatic pancreatic carcinoma and BRCA2 mutatio...

[CHEK2 c.1100delC may not contribute to genetic background of hereditary breast…

Song(Chuan-gui),Hu(Zhen),Yuan(Wen-tao),Di(Ge… Zhonghua Yi Xue Yi Chuan Xue … 2009-03-27

...BRCA2 familial/early-onset breast cancer patients in Shanghai.,One hundred and fourteen non-BRCA1/BRCA2 hereditary breas...

Breast cancer immunohistochemical features in young women with BRCA 1/2 mutatio…

Zakhartseva(L M),Gorovenko(N G),Podolskaya(S… Exp Oncol 2009-11-25

...BRCA2(6174delT) genes were screened using multiplex PCR in 99 patients.,Mutations of BRCA1/2 genes were found in 9.1% of...

Mammary tumor development in dogs is associated with BRCA1 and BRCA2.

Rivera(Patricio),Melin(Malin),Biagi(Tara),Fa… Cancer Res 2009-12-15

...BRCA2 but with a stronger association to BRCA1 in malignant cases. Both BRCA1 and BRCA2 showed odds ratios of approximat...

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