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BCCIP is required for the nuclear localization of the p21 protein.

Fan(Jinjiang),Wray(Justin),Meng(Xiangbing),S… Cell Cycle 2009-12-30

...BRCA2 and CDKN1A Interacting Protein. Previous reports showed that BCCIP enhances the p21 suppression activity towards C...

BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex …

Niwa(Takayoshi),Saito(Hiroko),Imajoh-ohmi(Sh… Cancer Sci 2009-11-03

...BRCA2) is localized mainly in the nucleus where it plays an important role in DNA damage repair. Some BRCA2 protein is a...

Pharmacologic treatment of male breast cancer.

Hayes(Teresa G) Expert Opin Pharmacother 2009-11-17

...BRCA2 or other genes. Male breast cancer occurs at an older age than female breast cancer and is frequently diagnosed at...

Dramatic response to platinum in a patient with cancer with a germline BRCA2 mu…

Moule(R),Sohaib(A),Eeles(R) Clin Oncol (R Coll Radiol) 2009-12-14

...BRCA2 gene who was exposed to platinum containing chemotherapy. She is cancer-free 10 years' later. Such cases provide c...

Germline variants of the promyelocytic leukemia tumor suppressor gene in patien…

Plevova(P),Walczyskova(S),Jeziskova(I),Jurck… Neoplasma 2009-11-17

...BRCA2, MLH1, MSH2, APC or TP53 genes did not detect a pathogenic germline mutation. Heteroduplex analysis and direct seq...

The counseling and management of young healthy BRCA mutation carriers.

Eitan(Ram),Michaelson-Cohen(Rachel),Levavi(H… Int J Gynecol Cancer 2009-12-29

...BRCA2 genes and the associated increased risk of breast and ovarian cancers in mutation carriers, our understanding of t...

Transcription-associated recombination is independent of XRCC2 and mechanistica…

Savolainen(Linda),Helleday(Thomas) Nucleic Acids Res 2009-02-27

...BRCA2 protein and the RAD51 paralog protein XRCC2 are required for homologous recombination. Here, we show that the BRCA...

Development of PARP inhibitors in oncology.

Rodon(Jordi),Iniesta(Maria D),Papadopoulos(K… Expert Opin Investig Drugs 2009-07-20

...BRCA2 mutations) can lead to gross genomic instability and cell death. Likewise, combining PARP inhibition with cytotoxi...

BCCIP as a prognostic marker for radiotherapy of laryngeal cancer.

Rewari(Amar),Lu(Huimei),Parikh(Rahul),Yang(Q… Radiother Oncol 2009-05-20

...BRCA2 and CDKN1A interacting protein) is essential for maintaining the transactivation activity of wild type p53. We ana...

HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 prot…

Spardy(Nicole),Duensing(Anette),Hoskins(Eliz… Cancer Res 2009-01-16

...BRCA2 and MUS81. In line with these results, we found that FANCD2-containing APBs form in an ATR-dependent manner in HPV...

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