...BRCA2 mutations. Allele frequencies of these polymorphisms were investigated to determine if they modify risk in BRCA mu...
...BRCA2 mutations.,To cover the complete coding region and splice sites, we designed 112 PCR amplicons (136-435 bp), ampli...
...BRCA2 NA (BRCA2 siRNA) (Qiagen) as well as negative-control siRNA for 48 h were irradiated, and several critical end poi...
...BRCA2 carriers is higher, and cyclin D1 expression lower, than in sporadic tumors. In familial non-BRCA1/2 tumors, cycli...
...BRCA2 mutations, were analysed for the presence of ATM mutations. A total of 34 ATM sequence variants were detected: 1 d...
Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or othe...
...BRCA2-associated repressor protein. The aim was to investigate gene copy numbers of CCND1 and EMSY and to determine if C...
...BRCA2 with BRCAX tumors, the only parameter that differed was cyclin D1, which was significantly overexpressed in BRCA2 ...
Women with a BRCA1 or BRCA2 mutation are at an elevated risk of developing breast and ovarian cancer; however, it is unc...
...BRCA2 French Canadian families with a high risk of breast cancer and 95 healthy controls from the same population. Altho...
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