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Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BR…

Metcalfe(Kelly A),Lubinski(Jan),Ghadirian(Pa… J Clin Oncol 2008-04-15

...BRCA2 mutation who had been diagnosed with unilateral breast cancer were followed prospectively for a minimum of 1.5 yea...

Chronic hypoxia decreases synthesis of homologous recombination proteins to off…

Chan(Norman),Koritzinsky(Marianne),Zhao(Hele… Cancer Res 2008-02-14

...BRCA2 and siRNA to RAD51, we confirmed that the hypoxia-induced radiosensitivity was due to decreased HR capacity. Persi...

Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-depend…

Willems(Amber J),Dawson(Sarah-Jane),Samaratu… Clin Cancer Res 2008-08-18

...BRCA2 mutation, respectively. We examined LOH at the BRCA1 and BRCA2 genes using multiplex ligation-dependent probe ampl...

LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumo…

Ash(S C),Yang(D Q),Britt(D E) Biochem Biophys Res Commun 2008-06-16

...BRCA2-associated protein involved in cell cycle regulation and DNA repair. Here, we demonstrate association between LYRI...

Gastric cancer with high-level microsatellite instability: target gene mutation…

Falchetti(Mario),Saieva(Calogero),Lupi(Ramon… Hum Pathol 2008-07-01

...BRCA2, MRE11). Gastric cancer cases with MSI-H were found to accumulate heterozygous mutations affecting multiple molecu...

Genetic heterogeneity by comparative genomic hybridization in BRCAx breast canc…

Mangia(Anita),Chiarappa(Patrizia),Tommasi(St… Cancer Genet Cytogenet 2008-06-03

...BRCA2) were analyzed by comparative genomic hybridization (CGH) to investigate intratumor heterogeneity. This was the fi...

High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer.

Smirnova(T Yu),Pospekhova(N I),Lyubchenko(L … Bull Exp Biol Med 2008-03-11

...BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russia...

BRCA1/2 associated hereditary breast cancer.

Teng(Li-song),Zheng(Yi),Wang(Hao-hao) J Zhejiang Univ Sci B 2008-03-31

...BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary b...

Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient a…

Klovstad(Martha),Abdu(Uri),Schüpbach(Trudi) PLoS Genet 2008-06-04

...brca2. In addition, Brca2 co-immunoprecipitates with the checkpoint protein Rad9, suggesting a direct role for Brca2 in ...

BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast c…

Toh(Gaik Theng),Kang(Peter),Lee(Sharlene S W… PLoS One 2008-05-28

...BRCA2 sequence alterations, of which eight are novel (3 BRCA1 and 5 BRCA2). One deleterious BRCA1 mutation and 2 deleter...

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