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Genetic landscape of Chinese colorectal cancer: insights into germline and so...

Zhao(F),Lin(H),Han(R),Wang(M),Yang(L),Tian... BMC Cancer 2026-03-10

...BRCA2 and ATM mutations exceeded 10. CONCLUSIONS: Our findings offer a comprehensive overview of genetic susceptibility ...

Impact of Ethnicity on the Uptake of Risk Reducing Mastectomy in Unaffected B...

Mashal(S),Melanson(A),Apostolova(C),Ferrou... Ann Surg Oncol 2026-06-00

...BRCA2, and 21 (4.4%) in PALB2. The median age at genetic testing was 37 years (interquartile range [IQR], 29-47) and 365...

A novel CDK12 inhibitor induces homologous recombination deficiency to enhanc...

Kawahara(S),Taki(M),Hamanishi(J),Ebara(S),... Mol Cancer Ther 2026-03-12

...BRCA2, induced apoptosis and DNA damage, and inhibited tumor growth in USC PDX models with high CDK12 expression. Furthe...

Peritoneal cancer risk after risk reducing salpingo-oophorectomy, impact of m...

Saule(C),Laas(E),Weber(N),Bataillon(G),Bec... Gynecol Oncol 2026-05-00

...BRCA2 METHODS: We conducted an ambispective multicenter study in France including 1351 women at high risk of ovarian can...

Outcomes of multigene panel testing for hereditary cancer in two Israeli medi...

Laitman(Y),Zalmanoviz(S),Netzer(I),Bernste... Cancer Genet 2026-06-00

...BRCA2, MSH2, and MSH6 genes, has not been reported. Individuals who underwent MGPT after oncogenetic counseling between ...

[Pancreatic acinar cell carcinoma: Clinical and theranostic characteristics].

Marques(A),Mas(L),Dardenne(A),Paye(F),Andr... Bull Cancer 2026-06-00

...BRCA2, which may offer an opportunity for genetic counselling. Other molecular alterations, such as BRAF (approximately ...

Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in brea...

Khan(NU),Lei(H),Fu(J),Lei(R),Chen(X),Alqar... J Transl Med 2026-03-12

...BRCA2) are critical genes associated with hereditary breast cancer, and their mutation prevalence might greatly vary acr...

Prediction of Specific Survival and Clinicopathological Impact of Somatic PAL...

Hawsawi(YM),Mansoor(I),Sayan(M),Alsaleem(M... Int J Surg Pathol 2026-08-00

...BRCA2. To clarify the clinicopathological impact of somatic PALB2 variants, we analyzed tumor DNA extracted from formali...

Exploring the hereditary genetic mutational landscape of breast and ovarian c...

Tooming(M),Toome(K),Rekker(K),Roht(L),Laid... Sci Rep 2026-03-13

...BRCA2 (3.8%; 4.5%), and CHEK2 (3.5%; 1.7%). Two BRCA1 PV, c.5266dup and c.4035del, accounted for 29.1% of all PV detecte...

Predictors of Complications in Prophylactic Mastectomy and Direct-to-Implant ...

Wiesmeier(A),Prantl(L),Zemann(F),Eisenmann... J Clin Med 2026-03-09

...BRCA2. Patients who opt for breast removal are offered tailored reconstructive options based on their medical history an...

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