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DNA Strand Exchange to Monitor Human RAD51-Mediated Strand Invasion and Pairing.

Lahiri(S),Jensen(RB) Methods Mol Biol 2021-00-00

...BRCA2.

Monitoring Homologous Recombination Activity in Human Cells.

Vugic(D),Ehlén(Å),Carreira(A) Methods Mol Biol 2021-00-00

...BRCA2, RAD51C, and PALB2; which may help assess their pathogenicity. Here, we use the homologous recombination mediator ...

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future…

Perkhofer(L),Gout(J),Roger(E),Kude de Almeid… Gut 2021-00-00

...BRCA2, ATM and PALB2, occur frequently in both inherited and sporadic PDAC. Personalised treatment of pancreatic cancer ...

Lessons learned from understanding chemotherapy resistance in epithelial tubo-o…

Le Page(C),Amuzu(S),Rahimi(K),Gotlieb(W),Rag… Semin Cancer Biol 2021-12-00

BRCA1 and BRCA2 are multi-functional proteins and key factors for maintaining genomic stability through their roles in D...

Radiation-Related Deregulation of TUBB3 and BRCA1/2 and Risk of Secondary Lung …

Coco(S),Boccardo(S),Mora(M),Fontana(V),Vanni… Clin Breast Cancer 2021-00-00

...BRCA2 increase. Furthermore, BRCA2 and TUBB3 increased in ipsilateral lung cancer in women who had previously received r...

BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latin…

Lynce(F),Schlam(I),Geng(X),Peshkin(BN),Fried… J Genet Couns 2021-00-00

...BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds wh...

Prevalence of comprehensive DNA damage repair gene germline mutations in Chines…

Wu(J),Wei(Y),Pan(J),Jin(S),Gu(W),Gan(H),Zhu(… Int J Cancer 2021-00-01

...BRCA2 (5.3%), HFM1 (0.8%), ZSWIM7 (0.8%), MSH2 (0.8%) and MSH3 (0.8%). When compared with the cancer-free cohort, POLN a...

Time trends in uptake rates of risk-reducing mastectomy in Israeli asymptomatic…

Galmor(L),Bernstein-Molho(R),Sklair-Levy(M),… Breast Cancer Res Treat 2021-01-00

The rate of risk-reducing bilateral mastectomy (RRBM) among cancer-free Israeli female BRCA1/BRCA2 mutation carriers was...

Rapid Genetic Testing for BRCA1 and BRCA2 Mutations at the Time of Breast Cance…

Metcalfe(KA),Eisen(A),Poll(A),Candib(A),McCr… Ann Surg Oncol 2021-04-00

This study aimed to evaluate the impact of rapid genetic testing (RGT) for BRCA1 and BRCA2 at the time of breast cancer ...

The relationship between BRCA-associated breast cancer and age factors: an anal…

Okano(M),Nomizu(T),Tachibana(K),Nagatsuka(M)… J Hum Genet 2021-03-00

...BRCA2 pathogenic variant prevalence was 11.2% and 9.0% in the cohort of 2366 proband patients, respectively. The age at ...

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