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BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latin…

Lynce(F),Schlam(I),Geng(X),Peshkin(BN),Fried… J Genet Couns 2021-00-00

...BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds wh...

Prevalence of comprehensive DNA damage repair gene germline mutations in Chines…

Wu(J),Wei(Y),Pan(J),Jin(S),Gu(W),Gan(H),Zhu(… Int J Cancer 2021-00-01

...BRCA2 (5.3%), HFM1 (0.8%), ZSWIM7 (0.8%), MSH2 (0.8%) and MSH3 (0.8%). When compared with the cancer-free cohort, POLN a...

Time trends in uptake rates of risk-reducing mastectomy in Israeli asymptomatic…

Galmor(L),Bernstein-Molho(R),Sklair-Levy(M),… Breast Cancer Res Treat 2021-01-00

The rate of risk-reducing bilateral mastectomy (RRBM) among cancer-free Israeli female BRCA1/BRCA2 mutation carriers was...

Rapid Genetic Testing for BRCA1 and BRCA2 Mutations at the Time of Breast Cance…

Metcalfe(KA),Eisen(A),Poll(A),Candib(A),McCr… Ann Surg Oncol 2021-04-00

This study aimed to evaluate the impact of rapid genetic testing (RGT) for BRCA1 and BRCA2 at the time of breast cancer ...

The relationship between BRCA-associated breast cancer and age factors: an anal…

Okano(M),Nomizu(T),Tachibana(K),Nagatsuka(M)… J Hum Genet 2021-03-00

...BRCA2 pathogenic variant prevalence was 11.2% and 9.0% in the cohort of 2366 proband patients, respectively. The age at ...

Incidence of contralateral and ipsilateral breast cancers and prognosis in BRCA…

Yoshimura(A),Yokoyama(S),Iwata(H),Takaiso(N)… J Hum Genet 2021-04-00

...BRCA2 and non-BRCA1/2 pathogenic variant carriers were 4.0%, 2.9%, and 1.9%, respectively (P = 0.001). The annual averag...

Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pat…

Kobayashi(Y),Hirasawa(A),Chiyoda(T),Ueki(A),… Jpn J Clin Oncol 2021-02-08

...BRCA2 in 13 (65%) and 7 patients (35%), respectively. The median age at which risk-reducing salpingo-oophorectomy was pe...

Requirement of Bccip for the Regeneration of Intestinal Progenitors.

Lu(H),Ye(C),Liu(J),Rabson(AB),Verzi(M),De(S)… Am J Pathol 2021-00-00

...BRCA2 and CDKN1A/p21 interaction protein. Although a partial loss of BCCIP function is sufficient to trigger genomic ins...

Germline testing for homologous recombination repair genes-opportunities and ch…

Hirsch(S),Gieldon(L),Sutter(C),Dikow(N),Scha… Genes Chromosomes Cancer 2021-00-00

...BRCA2 genes are well known causes of hereditary breast and ovarian cancer. Other genes involved in the homologous recomb...

CRISPR-Cas9/long-read sequencing approach to identify cryptic mutations in BRCA…

Walsh(T),Casadei(S),Munson(KM),Eng(M),Mandel… J Med Genet 2021-00-00

...BRCA2 genomic regions from lymphoblast cells of patients with breast cancer, then sequenced these regions with long read...

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