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Evaluation of unclassified variants in the breast cancer susceptibility genes B…

Lee(Eunjung),McKean-Cowdin(Roberta),Ma(Huiya… Breast Cancer Res 2008-06-11

...BRCA2.,We sequenced BRCA1/BRCA2 in 1,469 population-based female breast cancer patients diagnosed between the ages of 20...

Better life expectancy in women with BRCA2 compared with BRCA1 mutations is att…

Byrd(Louise M),Shenton(Andrew),Maher(Eamonn … Cancer Epidemiol Biomarkers P… 2008-10-21

No formal assessment of life expectancy in women with BRCA1 and BRCA2 mutations in these genes has been reported previou...

Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHE…

Byrnes(Graham B),Southey(Melissa C),Hopper(J… Breast Cancer Res 2008-11-12

...BRCA2 mutation carriers. This is because the relative risk multiplies polygenic risk, and the latter is predicted by fam...

BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a populatio…

Soegaard(Marie),Kjaer(Susanne Kruger),Cox(Ma… Clin Cancer Res 2008-09-25

To evaluate the prevalence of BRCA1 and BRCA2 mutations and associations with clinical correlates of disease in a popula...

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 an…

Evers(Bastiaan),Drost(Rinske),Schut(Eva),de … Clin Cancer Res 2008-09-25

...BRCA2-deficient mouse mammary tumors and BRCA2-proficient control tumors. Subsequently, we assessed sensitivity of these...

A sensitive test for the detection of specific DSB repair defects in primary ce…

Keimling(Marlen),Kaur(Jatinder),Bagadi(Saran… Int J Cancer 2008-07-03

...BRCA2, and, thus, similar phenotypes to tumors with mutant alleles of BRCA1 and BRCA2. This suggests that detection of e...

BRCA1 and BRCA2 missense variants of high and low clinical significance influen…

Waddell(Nic),Ten Haaf(Anette),Marsh(Anna),Jo… PLoS Genet 2008-06-19

...BRCA2 pathogenic truncating and missense mutation carriers and familial breast cancer cases whose disease was not attrib...

A review of the clinical relevance of mismatch-repair deficiency in ovarian can…

Pal(Tuya),Permuth-Wey(Jenny),Sellers(Thomas … Cancer 2008-09-08

...BRCA2 mutations. An epigenetic mechanism known to cause inactivation of the MMR system is promoter hypermethylation of 1...

Genetic predisposition to breast cancer: past, present, and future.

Turnbull(Clare),Rahman(Nazneen) Annu Rev Genomics Hum Genet 2008-12-04

...BRCA2 are high-penetrance breast cancer predisposition genes identified by genome-wide linkage analysis and positional c...

The molecular pathology of hereditary breast cancer.

Palacios(J),Robles-Frías(M J),Castilla(M A),… Pathobiology 2008-07-22

...BRCA2 carcinomas, which tend to be estrogen and progesterone receptor positive. BRCA1 and BRCA2 loss of heterozygosity i...

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