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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated can…

Sakai(Wataru),Swisher(Elizabeth M),Karlan(Be… Nature 2008-03-31

...BRCA2 that restore the wild-type BRCA2 reading frame. First, in a cisplatin-resistant BRCA2-mutated breast-cancer cell l...

Resistance to therapy caused by intragenic deletion in BRCA2.

Edwards(Stacey L),Brough(Rachel),Lord(Christ… Nature 2008-03-31

...BRCA2-deficient cells with these revertant BRCA2 alleles rescued PARP inhibitor sensitivity and HR deficiency. Most of t...

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familia…

Snell(Cameron),Krypuy(Michael),Wong(Ee Ming)… Breast Cancer Res 2008-06-11

...BRCA2 germline mutations present. Methylation levels were tested by several quantitative techniques including MethyLight...

Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-asso…

Kauff(Noah D),Domchek(Susan M),Friebel(Tara … J Clin Oncol 2008-04-08

...BRCA2 mutations. Despite 17% to 39% of all BRCA mutation carriers having a mutation in BRCA2, no prospective study to da...

Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a …

Friebel(Tara M),Domchek(Susan M),Neuhausen(S… Clin Breast Cancer 2008-03-06

Women with BRCA1 or BRCA2 (BRCA1/2) mutations can reduce cancer incidence and mortality by using bilateral prophylactic ...

Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese pati…

Sugano(Kokichi),Nakamura(Seigo),Ando(Jiro),T… Cancer Sci 2008-12-17

...BRCA2 mutations in 19 subjects (14.1%). Subjects were classified into five groups and 22 subgroups according to their pe...

Cancer incidence in relatives of British Fanconi Anaemia patients.

Tischkowitz(Marc),Easton(Douglas F),Ball(Jan… BMC Cancer 2008-10-07

...BRCA2, D2, E, F, G, I, J/BRIP1, L, M and N/PALB2). Previous studies of cancer incidence in relatives of Fanconi anemia c...

Impaired tamoxifen metabolism reduces survival in familial breast cancer patien…

Newman(William G),Hadfield(Kristen D),Latif(… Clin Cancer Res 2008-10-08

...BRCA2) with familial breast cancer who had been treated with 20-mg tamoxifen following surgery.,Eight (7%) individuals h...

Association of common PALB2 polymorphisms with breast cancer risk: a case-contr…

Chen(Peizhan),Liang(Jie),Wang(Zhanwei),Zhou(… Clin Cancer Res 2008-10-08

...BRCA2-mediated DNA double-strand break repair and intra-S phase DNA damage checkpoint control, and its mutations are mod...

[Fertility preservation in female oncology patients].

Jenninga(E),Kroep(J R),Hilders(C G J M),Louw… Ned Tijdschr Geneeskd 2008-12-29

...BRCA2 gene mutation carriage was not carried out and more recently follow-up oocyte donation options are being considere...

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