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Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of …

Antoniou(A C),Hardy(R),Walker(L),Evans(D G),… J Med Genet 2008-09-18

Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for th...

Coordinated prophylactic surgical management for women with hereditary breast-o…

Batista(Larissa I),Lu(Karen H),Beahm(Elisabe… BMC Cancer 2008-05-13

...BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. T...

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PA…

Turner(Nicholas C),Lord(Christopher J),Iorns… EMBO J 2008-06-11

Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or othe...

Genetic alterations of CCND1 and EMSY in breast cancers.

Kirkegaard(T),Nielsen(K V),Jensen(L B),Campb… Histopathology 2008-07-08

...BRCA2-associated repressor protein. The aim was to investigate gene copy numbers of CCND1 and EMSY and to determine if C...

The homologous recombination system of Ustilago maydis.

Holloman(William K),Schirawski(Jan),Holliday… Fungal Genet Biol 2008-09-30

...BRCA2 homolog and its modifier Dss1 rather than Rad52 as a mediator of Rad51, the presence of only a single Rad51 paralo...

Ethical issues related to BRCA gene testing in orthodox Jewish women.

Mor(Pnina),Oberle(Kathleen) Nurs Ethics 2008-09-24

...BRCA2, have a greatly increased risk of developing breast and/or ovarian cancer. The incidence of BRCA gene mutation is ...

Artesunate derived from traditional Chinese medicine induces DNA damage and rep…

Li(Paul C H),Lam(Elena),Roos(Wynand P),Zdzie… Cancer Res 2008-08-15

...BRCA2, respectively, were more sensitive to artesunate than the corresponding wild-type. This was also true for XR-V15B ...

Marine natural product libraries for high-throughput screening and rapid drug d…

Bugni(Tim S),Richards(Burt),Bhoite(Leen),Cim… J Nat Prod 2008-09-12

...BRCA2-deficient cells.

Inherited cancer predisposition syndromes in Greece.

Apessos(Angela),Papadopoulou(Eirini),Belogia… Anticancer Res 2008-06-05

...BRCA2), and the rearranged during transfection protooncogene RET which is responsible for multiple endocrine neoplasia t...

Therapeutic exploitation of tumor cell defects in homologous recombination.

Powell(Simon N),Kachnic(Lisa A) Anticancer Agents Med Chem 2008-06-23

...BRCA2 genes were cloned, much has been learned about the function of these two major causes of familial breast cancer. B...

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