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Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate C…

Giri(VN),Knudsen(KE),Kelly(WK),Cheng(HH),Coo… J Clin Oncol 2020-00-20

...BRCA2, BRCA1, and mismatch repair genes, with broader testing, such as ATM, for clinical trial eligibility. BRCA2 was re...

The reduction of CA 125 serum levels in BRCA 1/2 mutation carriers after risk-r…

Grandi(G),Del Savio(MC),Sammarini(M),Cortesi… Eur J Cancer Prev 2020-00-00

...BRCA2 mutation carriers, not hysterectomised, >35 years old and with completed childbearing, were recruited. Some women ...

Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and…

Álvarez-Quilón(A),Wojtaszek(JL),Mathieu(MC),… Mol Cell 2020-00-18

...BRCA2, making APE2 a prime target for homologous recombination-defective cancers. However, because the function of APE2 ...

PALB2 as a potential prognostic biomarker for colorectal cancer.

Pan(W),Lu(K),Wang(W),Yao(J),Hou(Y) Comput Biol Chem 2020-05-20

...BRCA2 (PALB2) is regarded as a colorectal cancer (CRC) risk gene, but the prognostic implication of PALB2 in CRC remains...

Practical implementation of frailty models in Mendelian risk prediction.

Huang(T),Gorfine(M),Hsu(L),Parmigiani(G),Bra… Genet Epidemiol 2020-00-00

...BRCA2 genes to predict breast and ovarian cancer. We evaluate the proposed model's performance in simulations and real d...

Contralateral breast cancer and tumor recurrence in BRCA1/2 carriers and non-ca…

Allué Cabañuz(M),Domingo Bretón(M),Chóliz Ez… Cir Esp (Engl Ed) 2020-12-00

...BRCA2 and 25 at high-risk without mutation. Median follow-up 79 months. 16 patients recently diagnosed and 30 previously...

Germline Genetic Mutations in a Multi-center Contemporary Cohort of 550 Phyllod…

Rosenberger(LH),Thomas(SM),Nimbkar(SN),Hieke… Ann Surg Oncol 2020-10-00

...BRCA2 tested. Of 34 patients tested, 8.8% had a deleterious mutation (1 BRCA1, 2 TP53), and 5.9% had a BRCA2 VUS. Of wom...

Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Tr…

Qin(N),Wang(Z),Liu(Q),Song(N),Wilson(CL),Ehr… J Clin Oncol 2020-00-20

...BRCA2, among others) in 508 (11.5%) survivors. Mutations in homologous recombination (HR) genes were significantly assoc...

Clinical outcome and toxicity from taxanes in breast cancer patients with BRCA1…

Bayraktar(S),Zhou(JZ),Bassett(R),Gutierrez B… Breast J 2020-00-00

...BRCA2 proteins play a role in DNA damage repair, we postulated that taxane-related toxicity is potentially higher and cl...

"It wasn't just for me": Motivations and implications of genetic testing for wo…

Gill(G),Beard(C),Storey(K),Taylor(S),Sexton(… Psychooncology 2020-00-00

...BRCA2 is why most women present to familial cancer centers. Despite being assessed as low risk for HBOC, many women proc...

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