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Analysis of 3297 individuals suggests that the pathogenic germline 5'-UTR varia…

Laner(A),Benet-Pages(A),Neitzel(B),Holinski-… Fam Cancer 2020-00-00

...BRCA2 pathogenic variant. A total of 3297 individuals with suspicion of hereditary breast and ovarian cancer and fulfill...

BRCA1 Promoter Methylation Status in 1031 Primary Breast Cancers Predicts Favor…

Stefansson(OA),Hilmarsdottir(H),Olafsdottir(… JNCI Cancer Spectr 2020-04-00

...BRCA2, and five were BRCA1 germline mutation carriers. All cases were examined with respect to clinicopathological param...

The RAD52 S346X variant reduces risk of developing breast cancer in carriers of…

Adamson(AW),Ding(YC),Mendez-Dorantes(C),Bail… Mol Oncol 2020-00-00

...BRCA2, demonstrating the reciprocal roles for RAD52 and BRCA2 in the control of DSB repair by SSA. From an immunofluores...

ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.

Jette(NR),Kumar(M),Radhamani(S),Arthur(G),Go… Cancers (Basel) 2020-03-14

...BRCA2, with many more potential applications under study and in clinical trials. Here, we discuss the potential for exte...

Sensitivity-Enhanced 13 C-NMR Spectroscopy for Monitoring Multisite Phosphoryla…

Alik(A),Bouguechtouli(C),Julien(M),Bermel(W)… Angew Chem Int Ed Engl 2020-00-22

...BRCA2, and Oct4.

Comparing PI3K/Akt Inhibitors Used in Ovarian Cancer Treatment.

Wu(YH),Huang(YF),Chen(CC),Huang(CY),Chou(CY) Front Pharmacol 2020-00-00

...BRCA2 mRNA expression and p-ERK protein expression in OVCAR-8 cells with the KRAS mutation. This study highlights the im...

Pathologic findings and clinical outcomes in women undergoing risk-reducing sur…

Rush(SK),Swisher(EM),Garcia(RL),Pennington(K… Gynecol Oncol 2020-00-00

...BRCA2, 27 (4.2%) other HRR genes, and 15 (2.3%) Lynch Syndrome-associated genes. Seventeen (2.6%) had occult neoplasms a...

Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma an…

Ömeroğlu Şimşek(G),Ağababaoğlu(İ),Dursun(D),… Turk Gogus Kalp Damar Cerrahi… 2020-01-00

...BRCA2, CDK7, MLH3, MSH4, NEIL3, SMUG1, UNG, XRCC2, and XRCC4 genes showed more than five-fold higher expression in the p...

Prognostic Value of Germline DNA Repair Gene Mutations in De Novo Metastatic an…

Wei(Y),Wu(J),Gu(W),Wang(J),Lin(G),Qin(X),Dai… Oncologist 2020-00-00

...BRCA2 carriers (6.3 vs. 13.2 months; HR, 3.73; p < .001). Subgroup analysis revealed that the presence of gDDRm indicate...

Perceptions of risk and reward in BRCA1 and BRCA2 mutation carriers choosing sa…

Ghezelayagh(TS),Stewart(LE),Norquist(BM),Bow… Fam Cancer 2020-00-00

...BRCA2 (BRCA) mutation carriers choosing salpingectomy for ovarian cancer prevention. This was a longitudinal survey stud...

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