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Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-c…

Risch(Harvey A),McLaughlin(John R),Cole(Davi… J Natl Cancer Inst 2007-01-23

...BRCA2 mutations, respectively, were 0.32% (95% CI = 0.23% to 0.45%) and 0.69% (95% CI = 0.43% to 1.10%).,BRCA1 and BRCA2...

Constitutive activation of MAPK/ERK inhibits prostate cancer cell proliferation…

Moro(Loredana),Arbini(Arnaldo A),Marra(Ersil… Int J Oncol 2007-01-31

...BRCA2 and cell proliferation. PNT1A cell adhesion to ECM triggered MAPK/ERK signaling resulting in upregulation of BRCA2...

Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in…

Pepe(C),Guidugli(L),Sensi(E),Aretini(P),D'An… Breast Cancer Res Treat 2007-09-19

...BRCA2 carriers and in 108 sporadic breast cancer cases as a control group. The genotype analysis has been performed by m...

Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing brea…

Shanley(Susan),McReynolds(Kate),Ardern-Jones… Clin Cancer Res 2007-11-28

To undertake the first substantial clinical study of breast radiotherapy toxicity in BRCA1 and BRCA2 mutation carriers i...

Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutatio…

Shanley(Susan),McReynolds(Kate),Ardern-Jones… Clin Cancer Res 2007-11-28

...BRCA2 mutation carriers. Toxicity was documented using the Eastern Cooperative Oncology Group Common Toxicity Criteria f...

BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype bas…

Bane(Anita L),Beck(Jeanne C),Bleiweiss(Ira),… Am J Surg Pathol 2007-02-06

...BRCA2-associated breast cancers is less certain. To comprehensively characterize BRCA2-associated breast cancers we perf...

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibi…

Rahman(Nazneen),Seal(Sheila),Thompson(Debora… Nat Genet 2007-04-23

...BRCA2, and biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause Fanconi anemi...

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose t…

Reid(Sarah),Schindler(Detlev),Hanenberg(Helm… Nat Genet 2007-04-23

...BRCA2. Biallelic BRCA2 mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood malignancies. We identif...

Ductal carcinoma in situ in BRCA mutation carriers.

Hwang(E Shelley),McLennan(Jane L),Moore(Dan … J Clin Oncol 2007-03-27

...BRCA2 to estimate DCIS prevalence and incidence in known BRCA-positive women compared with high-risk women who were muta...

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

Xia(Bing),Dorsman(Josephine C),Ameziane(Naji… Nat Genet 2007-04-23

The Fanconi anemia and BRCA networks are considered interconnected, as BRCA2 gene defects have been discovered in indivi...

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