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Allele frequency trajectories across age groups reveal ongoing natural select...

Chen(JL),Kang(ML),Lin(CJ),Lo(YH),Chen(YJ),... Am J Hum Genet 2026-08-06

...BRCA2 and MLH1 suggest recurrent selective trade-offs in DNA repair genes. Phenome-wide association analysis across 30 h...

Exon-Specific Targeted Analysis of BRCA1 and BRCA2 Mutations in Bangladeshi B...

Dutta(S),Rashid(SMM),Islam(S),Ahmed(SF),Ay... Cancer Inform None

...BRCA2. Comprehensive sequencing of the full lengths of BRCA1 and BRCA2 may be necessary to ensure confident clinical int...

A case of long-term survival in unresectable pancreatic cancer with BRCA germ...

Takahashi(K),Itoyama(R),Yamao(T),Sako(T),H... Clin J Gastroenterol 2026-08-00

...BRCA2 gene mutation was identified. The patient continued treatment with drugs except oxaliplatin. Lung metastasis appea...

Reinforcement learning-based dynamic ensemble for missense variant effect pre...

Abbas(SH),Wu(J),Shi(T) Comput Methods Programs Biomed 2026-07-30

...BRCA2, GenixRL achieved the best performance and ranked highest on 14 of 17 clinically significant genes in a zero-shot ...

Associations of TILs and genomic alterations in HER2+ early breast cancer.

Lu(S),Huang(J),Gu(Y),Wang(C),Shen(K),Fei(X... Endocr Relat Cancer 2026-08-01

...BRCA2 (9.6%). A higher TIL density was observed in TP53-wild-type, low-TMB or low-CNA tumors (P < 0.05). PIK3CA mutation...

Clinical and genomic determinants of extraordinary response and resistance to...

McKenzie(J),Howard(L),Park(JJ),Ashraf(B),S... Prostate Cancer Prostatic D... 2026-08-05

...BRCA2 (HR 2.12 [95%CI 1.02-4.42], p = 0.045) additionally associated with PFS, and RAD21 (HR 2.55 [95%CI 1.13-5.77], p =...

A Successful Multimodal Treatment for High-Grade Serous Ovarian Cancer with B...

Chu(HH),Liu(FY),Wang(CC),Lin(MC),Lai(CH) Case Rep Oncol None

...BRCA2 heterozygous deletion), which was controlled by adjuvant radiotherapy combined with nivolumab and nab-paclitaxel, ...

BRCA2-deficient endothelium: a hidden catalyst in angiotensin II-induced vasc...

Singh(A),Bu(S),Perron(AV),Bhatt(KS),Sandhu... J Hypertens 2026-10-01

...BRCA2 ) are well known to increase the risk of breast and ovarian cancers. Emerging evidence indicates that BRCA2 mutati...

Germline genetic risk and prostate cancer-specific mortality in a population-...

Lu(L),Xu(J),Shi(Z),Engelmann(V),Tran(H),We... Prostate Cancer Prostatic D... 2026-08-04

...BRCA2, MSH6, PALB2) were individually associated with increased PCSM and were defined as Tier-1. Aggregated PVs in seven...

Performance of PREMM5, clinical criteria, and immunohistochemistry for MMR pr...

Rodríguez-Olivares(JL),Aguilar-Y-Méndez(D)... PLoS One None

...BRCA2, 1 BRIP1, and 1 PALB2). Additionally, one individual harbored a monoallelic PV in MUTYH. The Amsterdam II criteria...

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